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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MLH1
All Species:
13.64
Human Site:
S372
Identified Species:
25
UniProt:
P40692
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40692
NP_000240.1
756
84601
S372
S
L
T
S
S
S
T
S
G
S
S
D
K
V
Y
Chimpanzee
Pan troglodytes
XP_001170274
756
84655
S372
S
L
T
S
S
S
T
S
G
S
S
D
K
V
Y
Rhesus Macaque
Macaca mulatta
XP_001087274
583
64794
N222
N
I
R
S
I
F
G
N
A
V
S
R
E
L
I
Dog
Lupus familis
XP_534219
757
84567
G372
G
A
T
P
S
S
T
G
S
G
D
K
V
Y
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9JK91
760
84662
S372
G
V
A
S
S
S
T
S
G
S
G
D
K
V
Y
Rat
Rattus norvegicus
P97679
757
84522
S372
G
I
A
S
S
S
T
S
G
S
G
D
K
V
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_418828
757
84832
G372
S
S
S
T
A
A
K
G
T
S
D
K
V
Y
A
Frog
Xenopus laevis
NP_001090545
750
84121
S369
A
S
S
T
S
Q
K
S
S
E
K
V
Y
A
H
Zebra Danio
Brachydanio rerio
NP_956953
724
80793
A363
A
K
A
S
S
S
S
A
D
P
Q
E
R
V
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001120100
716
81818
A351
L
K
T
R
L
P
K
A
D
I
T
K
E
V
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793318
745
83320
D369
G
Q
R
S
S
S
T
D
Q
V
Y
A
H
H
M
Poplar Tree
Populus trichocarpa
XP_002325965
747
83627
L363
Q
S
A
V
E
S
K
L
R
N
S
N
E
A
R
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P38920
769
87044
L372
S
D
R
N
R
K
S
L
R
Q
A
Q
V
V
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
76
93
N.A.
88.1
87
N.A.
N.A.
80
75.1
69.7
N.A.
N.A.
50.6
N.A.
60.3
Protein Similarity:
100
99.8
76.5
96.1
N.A.
93.9
93.3
N.A.
N.A.
88.1
85.9
81
N.A.
N.A.
70.7
N.A.
75.7
P-Site Identity:
100
100
13.3
26.6
N.A.
73.3
66.6
N.A.
N.A.
13.3
13.3
33.3
N.A.
N.A.
13.3
N.A.
26.6
P-Site Similarity:
100
100
46.6
26.6
N.A.
80
80
N.A.
N.A.
40
40
66.6
N.A.
N.A.
33.3
N.A.
26.6
Percent
Protein Identity:
34.7
N.A.
N.A.
N.A.
36
N.A.
Protein Similarity:
56.6
N.A.
N.A.
N.A.
58.5
N.A.
P-Site Identity:
13.3
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
33.3
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
8
31
0
8
8
0
16
8
0
8
8
0
16
16
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
0
0
0
0
8
16
0
16
31
0
0
0
% D
% Glu:
0
0
0
0
8
0
0
0
0
8
0
8
24
0
8
% E
% Phe:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% F
% Gly:
31
0
0
0
0
0
8
16
31
8
16
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
8
8
16
% H
% Ile:
0
16
0
0
8
0
0
0
0
8
0
0
0
0
8
% I
% Lys:
0
16
0
0
0
8
31
0
0
0
8
24
31
0
0
% K
% Leu:
8
16
0
0
8
0
0
16
0
0
0
0
0
8
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
8
0
0
8
0
0
0
8
0
8
0
8
0
0
0
% N
% Pro:
0
0
0
8
0
8
0
0
0
8
0
0
0
0
0
% P
% Gln:
8
8
0
0
0
8
0
0
8
8
8
8
0
0
0
% Q
% Arg:
0
0
24
8
8
0
0
0
16
0
0
8
8
0
8
% R
% Ser:
31
24
16
54
62
62
16
39
16
39
31
0
0
0
0
% S
% Thr:
0
0
31
16
0
0
47
0
8
0
8
0
0
0
0
% T
% Val:
0
8
0
8
0
0
0
0
0
16
0
8
24
54
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
8
0
8
16
31
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _