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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MLH1 All Species: 27.27
Human Site: S332 Identified Species: 50
UniProt: P40692 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P40692 NP_000240.1 756 84601 S332 R V Q Q H I E S K L L G S N S
Chimpanzee Pan troglodytes XP_001170274 756 84655 S332 R V Q Q H I E S K L L G S N S
Rhesus Macaque Macaca mulatta XP_001087274 583 64794 R182 K I L E I V G R Y S I H N A G
Dog Lupus familis XP_534219 757 84567 S332 R V Q Q H I E S K L L G S N S
Cat Felis silvestris
Mouse Mus musculus Q9JK91 760 84662 S332 R V Q Q H I E S K L L G S N S
Rat Rattus norvegicus P97679 757 84522 S332 R V Q Q H I E S K L L G S N S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_418828 757 84832 S332 R V Q Q H V E S K L L G S N S
Frog Xenopus laevis NP_001090545 750 84121 S329 R V Q Q H I E S K L L G S N S
Zebra Danio Brachydanio rerio NP_956953 724 80793 I323 E D S I I E S I Q K H I E N K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001120100 716 81818 H311 V N V H P T K H E V K F L H E
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_793318 745 83320 Q329 D I Q K C L E Q K L L G C N S
Poplar Tree Populus trichocarpa XP_002325965 747 83627 M323 A S K P F I Y M S I V L P P E
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P38920 769 87044 A332 K I A N Q L H A E L S A I D T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 76 93 N.A. 88.1 87 N.A. N.A. 80 75.1 69.7 N.A. N.A. 50.6 N.A. 60.3
Protein Similarity: 100 99.8 76.5 96.1 N.A. 93.9 93.3 N.A. N.A. 88.1 85.9 81 N.A. N.A. 70.7 N.A. 75.7
P-Site Identity: 100 100 0 100 N.A. 100 100 N.A. N.A. 93.3 100 6.6 N.A. N.A. 0 N.A. 53.3
P-Site Similarity: 100 100 40 100 N.A. 100 100 N.A. N.A. 100 100 13.3 N.A. N.A. 26.6 N.A. 73.3
Percent
Protein Identity: 34.7 N.A. N.A. N.A. 36 N.A.
Protein Similarity: 56.6 N.A. N.A. N.A. 58.5 N.A.
P-Site Identity: 6.6 N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: 26.6 N.A. N.A. N.A. 53.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 8 0 0 0 0 8 0 0 0 8 0 8 0 % A
% Cys: 0 0 0 0 8 0 0 0 0 0 0 0 8 0 0 % C
% Asp: 8 8 0 0 0 0 0 0 0 0 0 0 0 8 0 % D
% Glu: 8 0 0 8 0 8 62 0 16 0 0 0 8 0 16 % E
% Phe: 0 0 0 0 8 0 0 0 0 0 0 8 0 0 0 % F
% Gly: 0 0 0 0 0 0 8 0 0 0 0 62 0 0 8 % G
% His: 0 0 0 8 54 0 8 8 0 0 8 8 0 8 0 % H
% Ile: 0 24 0 8 16 54 0 8 0 8 8 8 8 0 0 % I
% Lys: 16 0 8 8 0 0 8 0 62 8 8 0 0 0 8 % K
% Leu: 0 0 8 0 0 16 0 0 0 70 62 8 8 0 0 % L
% Met: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % M
% Asn: 0 8 0 8 0 0 0 0 0 0 0 0 8 70 0 % N
% Pro: 0 0 0 8 8 0 0 0 0 0 0 0 8 8 0 % P
% Gln: 0 0 62 54 8 0 0 8 8 0 0 0 0 0 0 % Q
% Arg: 54 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % R
% Ser: 0 8 8 0 0 0 8 54 8 8 8 0 54 0 62 % S
% Thr: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 8 % T
% Val: 8 54 8 0 0 16 0 0 0 8 8 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 8 0 8 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _