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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MLH1
All Species:
27.88
Human Site:
S295
Identified Species:
51.11
UniProt:
P40692
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40692
NP_000240.1
756
84601
S295
T
H
P
F
L
Y
L
S
L
E
I
S
P
Q
N
Chimpanzee
Pan troglodytes
XP_001170274
756
84655
S295
T
H
P
F
L
Y
L
S
L
E
I
S
P
Q
N
Rhesus Macaque
Macaca mulatta
XP_001087274
583
64794
N145
P
P
K
P
C
A
G
N
Q
G
T
Q
I
T
V
Dog
Lupus familis
XP_534219
757
84567
S295
T
H
P
F
L
Y
L
S
L
E
I
S
P
Q
N
Cat
Felis silvestris
Mouse
Mus musculus
Q9JK91
760
84662
S295
T
H
P
F
L
Y
L
S
L
E
I
S
P
Q
N
Rat
Rattus norvegicus
P97679
757
84522
I295
T
H
P
F
L
Y
L
I
L
E
I
S
P
Q
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_418828
757
84832
S295
T
H
P
F
L
Y
L
S
L
E
I
A
P
K
N
Frog
Xenopus laevis
NP_001090545
750
84121
S292
T
H
P
F
L
Y
L
S
L
D
I
A
P
Q
N
Zebra Danio
Brachydanio rerio
NP_956953
724
80793
H286
A
Y
L
P
K
N
T
H
P
F
L
Y
L
S
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001120100
716
81818
M274
K
S
S
S
I
Q
K
M
L
E
E
L
Y
S
F
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793318
745
83320
S292
A
H
P
F
I
Y
F
S
L
E
I
A
P
H
N
Poplar Tree
Populus trichocarpa
XP_002325965
747
83627
T286
N
Y
V
A
K
K
T
T
M
V
L
F
I
N
D
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P38920
769
87044
G295
N
R
P
F
I
Y
L
G
I
V
I
D
P
A
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
76
93
N.A.
88.1
87
N.A.
N.A.
80
75.1
69.7
N.A.
N.A.
50.6
N.A.
60.3
Protein Similarity:
100
99.8
76.5
96.1
N.A.
93.9
93.3
N.A.
N.A.
88.1
85.9
81
N.A.
N.A.
70.7
N.A.
75.7
P-Site Identity:
100
100
0
100
N.A.
100
93.3
N.A.
N.A.
86.6
86.6
0
N.A.
N.A.
13.3
N.A.
66.6
P-Site Similarity:
100
100
6.6
100
N.A.
100
93.3
N.A.
N.A.
100
100
13.3
N.A.
N.A.
20
N.A.
80
Percent
Protein Identity:
34.7
N.A.
N.A.
N.A.
36
N.A.
Protein Similarity:
56.6
N.A.
N.A.
N.A.
58.5
N.A.
P-Site Identity:
0
N.A.
N.A.
N.A.
40
N.A.
P-Site Similarity:
33.3
N.A.
N.A.
N.A.
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
0
0
8
0
8
0
0
0
0
0
24
0
8
8
% A
% Cys:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
8
0
8
0
0
8
% D
% Glu:
0
0
0
0
0
0
0
0
0
62
8
0
0
0
0
% E
% Phe:
0
0
0
70
0
0
8
0
0
8
0
8
0
0
8
% F
% Gly:
0
0
0
0
0
0
8
8
0
8
0
0
0
0
0
% G
% His:
0
62
0
0
0
0
0
8
0
0
0
0
0
8
0
% H
% Ile:
0
0
0
0
24
0
0
8
8
0
70
0
16
0
0
% I
% Lys:
8
0
8
0
16
8
8
0
0
0
0
0
0
8
0
% K
% Leu:
0
0
8
0
54
0
62
0
70
0
16
8
8
0
8
% L
% Met:
0
0
0
0
0
0
0
8
8
0
0
0
0
0
0
% M
% Asn:
16
0
0
0
0
8
0
8
0
0
0
0
0
8
62
% N
% Pro:
8
8
70
16
0
0
0
0
8
0
0
0
70
0
0
% P
% Gln:
0
0
0
0
0
8
0
0
8
0
0
8
0
47
0
% Q
% Arg:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
8
8
8
0
0
0
54
0
0
0
39
0
16
0
% S
% Thr:
54
0
0
0
0
0
16
8
0
0
8
0
0
8
0
% T
% Val:
0
0
8
0
0
0
0
0
0
16
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
16
0
0
0
70
0
0
0
0
0
8
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _