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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GPX4
All Species:
26.06
Human Site:
Y180
Identified Species:
47.78
UniProt:
P36969
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P36969
NP_001034936.1
197
22175
Y180
N
G
C
V
V
K
R
Y
G
P
M
E
E
P
L
Chimpanzee
Pan troglodytes
NP_001139295
234
27030
Y217
N
G
C
V
V
K
R
Y
G
P
M
E
E
P
L
Rhesus Macaque
Macaca mulatta
NP_001112361
197
22033
Y180
N
G
C
V
V
K
R
Y
G
P
M
E
E
P
L
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
O70325
197
22060
Y180
N
G
C
V
V
K
R
Y
G
P
M
E
E
P
Q
Rat
Rattus norvegicus
P36970
197
22056
Y180
N
G
C
V
V
K
R
Y
G
P
M
E
E
P
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001165215
196
21788
F179
E
G
A
V
V
K
R
F
S
P
M
E
D
P
V
Zebra Danio
Brachydanio rerio
NP_001025241
191
21368
Y174
E
G
Q
V
V
K
R
Y
G
P
M
D
D
P
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001120847
201
23115
F184
E
G
K
V
V
S
R
F
A
P
T
V
D
P
L
Nematode Worm
Caenorhab. elegans
O02621
163
18406
D147
K
R
F
G
P
T
T
D
P
K
D
M
E
K
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002303583
251
27683
Y231
E
G
K
V
V
D
R
Y
A
P
T
T
S
P
L
Maize
Zea mays
NP_001146472
168
18439
Y148
E
G
R
V
V
D
R
Y
A
P
T
T
S
P
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O48646
232
25566
F211
D
G
N
V
V
D
R
F
A
P
T
T
S
P
L
Baker's Yeast
Sacchar. cerevisiae
P38143
162
18388
F143
N
G
K
V
V
Q
R
F
S
S
L
T
K
P
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
76.9
99.4
N.A.
N.A.
93.4
91.3
N.A.
N.A.
N.A.
68
67.5
N.A.
N.A.
48.2
38
N.A.
Protein Similarity:
100
77.3
99.4
N.A.
N.A.
96.4
95.4
N.A.
N.A.
N.A.
79.1
78.1
N.A.
N.A.
64.1
52.7
N.A.
P-Site Identity:
100
100
100
N.A.
N.A.
93.3
93.3
N.A.
N.A.
N.A.
60
66.6
N.A.
N.A.
46.6
6.6
N.A.
P-Site Similarity:
100
100
100
N.A.
N.A.
93.3
93.3
N.A.
N.A.
N.A.
80
80
N.A.
N.A.
60
6.6
N.A.
Percent
Protein Identity:
38.6
44.1
N.A.
39.2
35
N.A.
Protein Similarity:
53.7
57.3
N.A.
53.8
51.7
N.A.
P-Site Identity:
53.3
53.3
N.A.
46.6
40
N.A.
P-Site Similarity:
53.3
53.3
N.A.
60
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
0
0
0
31
0
0
0
0
0
0
% A
% Cys:
0
0
39
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
0
24
0
8
0
0
8
8
24
0
8
% D
% Glu:
39
0
0
0
0
0
0
0
0
0
0
47
47
0
0
% E
% Phe:
0
0
8
0
0
0
0
31
0
0
0
0
0
0
0
% F
% Gly:
0
93
0
8
0
0
0
0
47
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
8
0
24
0
0
54
0
0
0
8
0
0
8
8
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
54
% L
% Met:
0
0
0
0
0
0
0
0
0
0
54
8
0
0
0
% M
% Asn:
47
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
8
0
0
0
8
85
0
0
0
93
0
% P
% Gln:
0
0
8
0
0
8
0
0
0
0
0
0
0
0
16
% Q
% Arg:
0
8
8
0
0
0
93
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
8
0
0
16
8
0
0
24
0
16
% S
% Thr:
0
0
0
0
0
8
8
0
0
0
31
31
0
0
0
% T
% Val:
0
0
0
93
93
0
0
0
0
0
0
8
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
62
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _