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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GPX4
All Species:
31.52
Human Site:
T81
Identified Species:
57.78
UniProt:
P36969
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P36969
NP_001034936.1
197
22175
T81
G
K
T
E
V
N
Y
T
Q
L
V
D
L
H
A
Chimpanzee
Pan troglodytes
NP_001139295
234
27030
T118
G
K
T
E
V
N
Y
T
Q
L
V
D
L
H
A
Rhesus Macaque
Macaca mulatta
NP_001112361
197
22033
T81
G
K
T
E
V
N
Y
T
Q
L
V
D
L
H
A
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
O70325
197
22060
T81
G
K
T
D
V
N
Y
T
Q
L
V
D
L
H
A
Rat
Rattus norvegicus
P36970
197
22056
T81
G
K
T
D
V
N
Y
T
Q
L
V
D
L
H
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001165215
196
21788
T80
G
K
T
P
V
N
Y
T
Q
L
E
E
L
H
A
Zebra Danio
Brachydanio rerio
NP_001025241
191
21368
T75
G
K
T
P
V
N
Y
T
Q
L
A
A
M
H
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001120847
201
23115
R86
G
L
T
D
T
N
Y
R
E
L
V
Q
L
Y
E
Nematode Worm
Caenorhab. elegans
O02621
163
18406
E72
C
N
Q
F
A
G
Q
E
P
S
C
E
I
D
I
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002303583
251
27683
T133
G
L
T
D
S
N
Y
T
E
L
T
Q
L
Y
A
Maize
Zea mays
NP_001146472
168
18439
N72
E
I
L
A
F
P
C
N
Q
F
G
G
Q
E
P
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O48646
232
25566
T113
G
L
T
N
S
N
Y
T
E
L
A
Q
L
Y
E
Baker's Yeast
Sacchar. cerevisiae
P38143
162
18388
Q71
P
C
N
Q
F
G
K
Q
E
P
G
S
D
E
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
76.9
99.4
N.A.
N.A.
93.4
91.3
N.A.
N.A.
N.A.
68
67.5
N.A.
N.A.
48.2
38
N.A.
Protein Similarity:
100
77.3
99.4
N.A.
N.A.
96.4
95.4
N.A.
N.A.
N.A.
79.1
78.1
N.A.
N.A.
64.1
52.7
N.A.
P-Site Identity:
100
100
100
N.A.
N.A.
93.3
93.3
N.A.
N.A.
N.A.
80
66.6
N.A.
N.A.
46.6
0
N.A.
P-Site Similarity:
100
100
100
N.A.
N.A.
100
100
N.A.
N.A.
N.A.
86.6
73.3
N.A.
N.A.
66.6
13.3
N.A.
Percent
Protein Identity:
38.6
44.1
N.A.
39.2
35
N.A.
Protein Similarity:
53.7
57.3
N.A.
53.8
51.7
N.A.
P-Site Identity:
53.3
6.6
N.A.
46.6
0
N.A.
P-Site Similarity:
73.3
6.6
N.A.
60
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
8
0
0
0
0
0
16
8
0
0
54
% A
% Cys:
8
8
0
0
0
0
8
0
0
0
8
0
0
0
0
% C
% Asp:
0
0
0
31
0
0
0
0
0
0
0
39
8
8
0
% D
% Glu:
8
0
0
24
0
0
0
8
31
0
8
16
0
16
16
% E
% Phe:
0
0
0
8
16
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
77
0
0
0
0
16
0
0
0
0
16
8
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
54
0
% H
% Ile:
0
8
0
0
0
0
0
0
0
0
0
0
8
0
8
% I
% Lys:
0
54
0
0
0
0
8
0
0
0
0
0
0
0
0
% K
% Leu:
0
24
8
0
0
0
0
0
0
77
0
0
70
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% M
% Asn:
0
8
8
8
0
77
0
8
0
0
0
0
0
0
0
% N
% Pro:
8
0
0
16
0
8
0
0
8
8
0
0
0
0
8
% P
% Gln:
0
0
8
8
0
0
8
8
62
0
0
24
8
0
8
% Q
% Arg:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
16
0
0
0
0
8
0
8
0
0
0
% S
% Thr:
0
0
77
0
8
0
0
70
0
0
8
0
0
0
0
% T
% Val:
0
0
0
0
54
0
0
0
0
0
47
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
77
0
0
0
0
0
0
24
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _