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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K2
All Species:
8.48
Human Site:
S295
Identified Species:
15.56
UniProt:
P36507
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P36507
NP_109587.1
400
44424
S295
E
G
E
P
H
S
I
S
P
R
P
R
P
P
G
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
P287
E
G
D
A
A
E
T
P
P
R
P
R
T
P
G
Rhesus Macaque
Macaca mulatta
XP_001118016
505
55560
P400
D
G
Q
A
Q
A
W
P
A
G
S
Q
T
G
Q
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q63932
401
44418
P296
G
E
P
H
S
V
S
P
R
P
R
P
P
G
R
Rat
Rattus norvegicus
P36506
400
44263
S295
D
G
E
P
H
S
V
S
P
R
P
R
P
P
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511248
391
43070
T294
L
E
L
M
F
G
C
T
V
E
G
D
A
S
E
Chicken
Gallus gallus
Q90891
398
44059
S293
E
G
E
S
H
S
V
S
P
W
A
R
P
P
G
Frog
Xenopus laevis
Q05116
395
43724
A289
D
P
A
S
S
E
L
A
P
R
P
R
P
P
G
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
I267
G
Y
N
V
K
S
D
I
W
S
L
G
I
T
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24324
396
43851
E299
S
I
F
A
D
N
A
E
E
S
G
Q
P
T
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q10664
387
42776
E286
M
F
N
V
A
E
N
E
I
E
L
A
D
S
L
Sea Urchin
Strong. purpuratus
XP_781505
412
45737
G303
F
G
Y
E
L
Q
A
G
E
T
K
N
I
R
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9S7U9
363
39830
V256
D
I
W
S
L
G
L
V
V
L
E
C
A
T
G
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
79.5
70.8
N.A.
N.A.
93.7
94
N.A.
64.5
93.5
79
32
N.A.
62.2
N.A.
51.7
63.5
Protein Similarity:
100
87.5
72.4
N.A.
N.A.
97.2
98
N.A.
73
96.2
87.5
50.7
N.A.
78.2
N.A.
66.5
75.7
P-Site Identity:
100
53.3
6.6
N.A.
N.A.
6.6
86.6
N.A.
0
73.3
46.6
6.6
N.A.
6.6
N.A.
0
6.6
P-Site Similarity:
100
60
33.3
N.A.
N.A.
6.6
100
N.A.
6.6
80
66.6
6.6
N.A.
20
N.A.
0
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
32.7
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
50.2
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
24
16
8
16
8
8
0
8
8
16
0
0
% A
% Cys:
0
0
0
0
0
0
8
0
0
0
0
8
0
0
0
% C
% Asp:
31
0
8
0
8
0
8
0
0
0
0
8
8
0
8
% D
% Glu:
24
16
24
8
0
24
0
16
16
16
8
0
0
0
8
% E
% Phe:
8
8
8
0
8
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
16
47
0
0
0
16
0
8
0
8
16
8
0
16
47
% G
% His:
0
0
0
8
24
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
16
0
0
0
0
8
8
8
0
0
0
16
0
0
% I
% Lys:
0
0
0
0
8
0
0
0
0
0
8
0
0
0
8
% K
% Leu:
8
0
8
0
16
0
16
0
0
8
16
0
0
0
8
% L
% Met:
8
0
0
8
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
16
0
0
8
8
0
0
0
0
8
0
0
0
% N
% Pro:
0
8
8
16
0
0
0
24
39
8
31
8
47
39
0
% P
% Gln:
0
0
8
0
8
8
0
0
0
0
0
16
0
0
8
% Q
% Arg:
0
0
0
0
0
0
0
0
8
31
8
39
0
8
8
% R
% Ser:
8
0
0
24
16
31
8
24
0
16
8
0
0
16
0
% S
% Thr:
0
0
0
0
0
0
8
8
0
8
0
0
16
24
0
% T
% Val:
0
0
0
16
0
8
16
8
16
0
0
0
0
0
0
% V
% Trp:
0
0
8
0
0
0
8
0
8
8
0
0
0
0
0
% W
% Tyr:
0
8
8
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _