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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMGCL All Species: 20.61
Human Site: T89 Identified Species: 37.78
UniProt: P35914 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P35914 NP_000182.2 325 34360 T89 V P Q M G D H T E V L K G I Q
Chimpanzee Pan troglodytes XP_001166273 325 34328 T89 V P Q M G D H T E V L K G I Q
Rhesus Macaque Macaca mulatta XP_001104722 331 34676 A95 V P Q M A D H A E V L K G I Q
Dog Lupus familis XP_535360 325 34200 A89 V P Q M A D C A E V L K G I Q
Cat Felis silvestris
Mouse Mus musculus P38060 325 34142 S89 V P Q M A D H S D V L K G I Q
Rat Rattus norvegicus P97519 325 34173 S89 V P Q M A D H S D V L K G I Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P35915 298 31418 L71 V M Q G I N K L P G V S Y P V
Frog Xenopus laevis NP_001085152 328 34788 K92 V P Q M A D H K N V M Q G I K
Zebra Danio Brachydanio rerio A8WG57 335 35873 T99 V A Q M A D H T A V L K G I K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_609089 323 34155 A82 V P Q M G D N A E V L K G I R
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001196745 313 33056 T77 I P Q M G D H T D V M N G I T
Poplar Tree Populus trichocarpa XP_002308880 293 30640 G72 E A I R D F K G A R F P V L T
Maize Zea mays NP_001132253 434 44858 K191 V P Q L A D A K D V M E A V R
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 89.7 87 N.A. 87 88.9 N.A. N.A. 72.9 71.3 64.7 N.A. 59.3 N.A. N.A. 63.6
Protein Similarity: 100 100 91.2 90.7 N.A. 93.8 95.6 N.A. N.A. 83 82.6 77.9 N.A. 75 N.A. N.A. 78.4
P-Site Identity: 100 100 86.6 80 N.A. 80 80 N.A. N.A. 13.3 60 73.3 N.A. 80 N.A. N.A. 66.6
P-Site Similarity: 100 100 86.6 80 N.A. 93.3 93.3 N.A. N.A. 26.6 80 80 N.A. 93.3 N.A. N.A. 86.6
Percent
Protein Identity: 57.8 48.1 N.A. N.A. N.A. N.A.
Protein Similarity: 70.7 60.1 N.A. N.A. N.A. N.A.
P-Site Identity: 0 33.3 N.A. N.A. N.A. N.A.
P-Site Similarity: 6.6 73.3 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 16 0 0 54 0 8 24 16 0 0 0 8 0 0 % A
% Cys: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 8 85 0 0 31 0 0 0 0 0 0 % D
% Glu: 8 0 0 0 0 0 0 0 39 0 0 8 0 0 0 % E
% Phe: 0 0 0 0 0 8 0 0 0 0 8 0 0 0 0 % F
% Gly: 0 0 0 8 31 0 0 8 0 8 0 0 77 0 0 % G
% His: 0 0 0 0 0 0 62 0 0 0 0 0 0 0 0 % H
% Ile: 8 0 8 0 8 0 0 0 0 0 0 0 0 77 0 % I
% Lys: 0 0 0 0 0 0 16 16 0 0 0 62 0 0 16 % K
% Leu: 0 0 0 8 0 0 0 8 0 0 62 0 0 8 0 % L
% Met: 0 8 0 77 0 0 0 0 0 0 24 0 0 0 0 % M
% Asn: 0 0 0 0 0 8 8 0 8 0 0 8 0 0 0 % N
% Pro: 0 77 0 0 0 0 0 0 8 0 0 8 0 8 0 % P
% Gln: 0 0 93 0 0 0 0 0 0 0 0 8 0 0 47 % Q
% Arg: 0 0 0 8 0 0 0 0 0 8 0 0 0 0 16 % R
% Ser: 0 0 0 0 0 0 0 16 0 0 0 8 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 31 0 0 0 0 0 0 16 % T
% Val: 85 0 0 0 0 0 0 0 0 85 8 0 8 8 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _