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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GCK
All Species:
40
Human Site:
Y108
Identified Species:
73.33
UniProt:
P35557
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35557
NP_000153.1
465
52191
Y108
V
K
T
K
H
Q
M
Y
S
I
P
E
D
A
M
Chimpanzee
Pan troglodytes
XP_001143661
465
52172
Y108
V
K
T
K
H
Q
M
Y
S
I
P
E
D
A
M
Rhesus Macaque
Macaca mulatta
XP_001093035
458
51285
Y101
V
K
T
K
H
Q
M
Y
S
I
P
E
D
A
M
Dog
Lupus familis
XP_532991
909
101134
Y104
V
E
M
E
N
Q
I
Y
A
I
P
E
D
L
M
Cat
Felis silvestris
Mouse
Mus musculus
P52792
465
52070
Y108
V
K
T
K
H
Q
M
Y
S
I
P
E
D
A
M
Rat
Rattus norvegicus
P17712
465
52098
Y108
V
K
T
K
H
Q
M
Y
S
I
P
E
D
A
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520120
593
65484
Y146
V
K
T
K
H
Q
L
Y
S
I
P
T
D
A
M
Chicken
Gallus gallus
NP_989543
916
102399
Y112
V
E
M
E
S
Q
I
Y
E
I
H
E
D
L
M
Frog
Xenopus laevis
NP_001079298
458
51069
Y101
V
E
T
K
H
K
M
Y
S
I
P
V
D
A
M
Zebra Danio
Brachydanio rerio
NP_998231
919
102145
Y112
V
E
M
E
N
Q
I
Y
A
I
S
E
N
I
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9NFT7
486
53467
Y130
V
E
T
M
S
K
G
Y
N
F
P
Q
T
L
M
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q42525
496
53688
V129
V
K
Q
E
F
E
E
V
S
I
P
P
H
L
M
Baker's Yeast
Sacchar. cerevisiae
P04807
486
53924
R113
D
T
T
Q
S
K
Y
R
L
P
D
A
M
R
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.2
30.7
N.A.
95.9
96.9
N.A.
71.8
30.2
79.3
28.8
N.A.
40.9
N.A.
N.A.
N.A.
Protein Similarity:
100
100
98.2
39.4
N.A.
98.2
98.7
N.A.
75.3
39.9
89.8
39
N.A.
62.5
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
53.3
N.A.
100
100
N.A.
86.6
46.6
80
40
N.A.
33.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
86.6
N.A.
100
100
N.A.
93.3
66.6
93.3
80
N.A.
60
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
32.4
28.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
53
53.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
40
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
53.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
16
0
0
8
0
54
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
0
0
0
0
0
0
8
0
70
0
0
% D
% Glu:
0
39
0
31
0
8
8
0
8
0
0
62
0
0
0
% E
% Phe:
0
0
0
0
8
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
54
0
0
0
0
0
8
0
8
0
0
% H
% Ile:
0
0
0
0
0
0
24
0
0
85
0
0
0
8
0
% I
% Lys:
0
54
0
54
0
24
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
8
0
8
0
0
0
0
31
0
% L
% Met:
0
0
24
8
0
0
47
0
0
0
0
0
8
0
93
% M
% Asn:
0
0
0
0
16
0
0
0
8
0
0
0
8
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
8
77
8
0
0
0
% P
% Gln:
0
0
8
8
0
70
0
0
0
0
0
8
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
8
0
0
0
0
0
8
0
% R
% Ser:
0
0
0
0
24
0
0
0
62
0
8
0
0
0
0
% S
% Thr:
0
8
70
0
0
0
0
0
0
0
0
8
8
0
8
% T
% Val:
93
0
0
0
0
0
0
8
0
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
85
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _