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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GCK
All Species:
34.24
Human Site:
T437
Identified Species:
62.78
UniProt:
P35557
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35557
NP_000153.1
465
52191
T437
L
T
P
S
C
E
I
T
F
I
E
S
E
E
G
Chimpanzee
Pan troglodytes
XP_001143661
465
52172
T437
L
T
P
S
C
E
I
T
F
I
E
S
E
E
G
Rhesus Macaque
Macaca mulatta
XP_001093035
458
51285
T430
L
T
P
S
C
E
I
T
F
I
E
S
E
E
G
Dog
Lupus familis
XP_532991
909
101134
S881
L
A
P
K
C
D
V
S
F
L
E
S
E
D
G
Cat
Felis silvestris
Mouse
Mus musculus
P52792
465
52070
T437
L
T
P
N
C
E
I
T
F
I
E
S
E
E
G
Rat
Rattus norvegicus
P17712
465
52098
T437
L
T
P
N
C
E
I
T
F
I
E
S
E
E
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520120
593
65484
T475
L
A
P
C
C
E
I
T
F
I
Q
S
E
E
G
Chicken
Gallus gallus
NP_989543
916
102399
T889
L
S
P
C
C
E
V
T
F
L
Q
S
E
D
G
Frog
Xenopus laevis
NP_001079298
458
51069
T430
L
T
S
G
C
E
I
T
F
I
Q
S
E
E
G
Zebra Danio
Brachydanio rerio
NP_998231
919
102145
R443
L
V
P
D
C
D
V
R
F
L
R
S
E
D
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9NFT7
486
53467
V463
G
V
K
F
E
L
V
V
S
E
D
G
S
G
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q42525
496
53688
G467
L
L
G
D
E
A
S
G
S
V
E
V
T
H
S
Baker's Yeast
Sacchar. cerevisiae
P04807
486
53924
K452
S
L
D
D
Y
P
I
K
I
V
P
A
E
D
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.2
30.7
N.A.
95.9
96.9
N.A.
71.8
30.2
79.3
28.8
N.A.
40.9
N.A.
N.A.
N.A.
Protein Similarity:
100
100
98.2
39.4
N.A.
98.2
98.7
N.A.
75.3
39.9
89.8
39
N.A.
62.5
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
53.3
N.A.
93.3
93.3
N.A.
80
60
80
46.6
N.A.
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
86.6
N.A.
100
100
N.A.
86.6
93.3
86.6
73.3
N.A.
13.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
32.4
28.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
53
53.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
16
0
0
0
8
0
0
0
0
0
8
0
0
0
% A
% Cys:
0
0
0
16
77
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
24
0
16
0
0
0
0
8
0
0
31
0
% D
% Glu:
0
0
0
0
16
62
0
0
0
8
54
0
85
54
0
% E
% Phe:
0
0
0
8
0
0
0
0
77
0
0
0
0
0
0
% F
% Gly:
8
0
8
8
0
0
0
8
0
0
0
8
0
8
85
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
0
0
0
0
0
0
62
0
8
54
0
0
0
0
0
% I
% Lys:
0
0
8
8
0
0
0
8
0
0
0
0
0
0
0
% K
% Leu:
85
16
0
0
0
8
0
0
0
24
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
16
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
70
0
0
8
0
0
0
0
8
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
24
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
8
0
0
8
0
0
0
8
% R
% Ser:
8
8
8
24
0
0
8
8
16
0
0
77
8
0
8
% S
% Thr:
0
47
0
0
0
0
0
62
0
0
0
0
8
0
0
% T
% Val:
0
16
0
0
0
0
31
8
0
16
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _