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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GCK
All Species:
22.42
Human Site:
S263
Identified Species:
41.11
UniProt:
P35557
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35557
NP_000153.1
465
52191
S263
E
W
G
A
F
G
D
S
G
E
L
D
E
F
L
Chimpanzee
Pan troglodytes
XP_001143661
465
52172
S263
E
W
G
A
F
G
D
S
G
E
L
D
E
F
L
Rhesus Macaque
Macaca mulatta
XP_001093035
458
51285
S256
E
W
G
A
F
G
D
S
G
E
L
D
E
F
L
Dog
Lupus familis
XP_532991
909
101134
D259
E
W
G
A
F
G
D
D
G
I
L
D
D
F
R
Cat
Felis silvestris
Mouse
Mus musculus
P52792
465
52070
S263
E
W
G
A
F
G
N
S
G
E
L
D
E
F
L
Rat
Rattus norvegicus
P17712
465
52098
S263
E
W
G
A
F
G
D
S
G
E
L
D
E
F
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520120
593
65484
A301
E
W
G
A
F
G
A
A
G
E
L
D
D
F
L
Chicken
Gallus gallus
NP_989543
916
102399
N715
E
W
G
A
F
G
D
N
G
C
L
D
D
I
Q
Frog
Xenopus laevis
NP_001079298
458
51069
T256
E
W
G
A
F
G
D
T
G
E
L
E
D
F
R
Zebra Danio
Brachydanio rerio
NP_998231
919
102145
D267
E
W
G
A
F
G
D
D
G
A
L
D
D
L
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9NFT7
486
53467
N289
E
W
G
A
F
G
D
N
G
V
L
E
F
V
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q42525
496
53688
F288
I
N
M
E
W
G
N
F
R
S
S
H
L
P
L
Baker's Yeast
Sacchar. cerevisiae
P04807
486
53924
N275
C
E
Y
G
S
F
D
N
E
H
V
V
L
P
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.2
30.7
N.A.
95.9
96.9
N.A.
71.8
30.2
79.3
28.8
N.A.
40.9
N.A.
N.A.
N.A.
Protein Similarity:
100
100
98.2
39.4
N.A.
98.2
98.7
N.A.
75.3
39.9
89.8
39
N.A.
62.5
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
73.3
N.A.
93.3
100
N.A.
80
66.6
73.3
66.6
N.A.
60
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
80
N.A.
100
100
N.A.
93.3
80
93.3
73.3
N.A.
73.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
32.4
28.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
53
53.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
85
0
0
8
8
0
8
0
0
0
0
0
% A
% Cys:
8
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
77
16
0
0
0
70
39
0
0
% D
% Glu:
85
8
0
8
0
0
0
0
8
54
0
16
39
0
0
% E
% Phe:
0
0
0
0
85
8
0
8
0
0
0
0
8
62
0
% F
% Gly:
0
0
85
8
0
93
0
0
85
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
8
0
8
0
0
0
% H
% Ile:
8
0
0
0
0
0
0
0
0
8
0
0
0
8
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
85
0
16
8
54
% L
% Met:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
0
0
0
16
24
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
16
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% Q
% Arg:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
39
% R
% Ser:
0
0
0
0
8
0
0
39
0
8
8
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
8
8
8
0
8
0
% V
% Trp:
0
85
0
0
8
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _