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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CBS
All Species:
26.06
Human Site:
S525
Identified Species:
52.12
UniProt:
P35520
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35520
NP_000062.1
551
60587
S525
Y
H
S
T
G
K
S
S
Q
R
Q
M
V
F
G
Chimpanzee
Pan troglodytes
XP_001142443
593
64952
S525
Y
H
S
T
G
K
S
S
Q
R
Q
M
V
F
G
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_853796
764
82787
S720
R
H
G
S
E
K
S
S
K
R
Q
T
V
F
R
Cat
Felis silvestris
Mouse
Mus musculus
Q91WT9
561
61525
S535
D
C
S
N
G
M
S
S
K
Q
Q
M
V
F
G
Rat
Rattus norvegicus
P32232
561
61436
S535
D
R
N
N
G
V
S
S
K
Q
L
M
V
F
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511742
606
66744
T560
A
T
A
S
P
R
D
T
K
Q
K
H
E
T
V
Chicken
Gallus gallus
XP_416752
558
61762
S530
Y
H
T
D
G
S
S
S
K
R
Q
M
V
F
G
Frog
Xenopus laevis
NP_001086820
562
62067
S518
Y
H
S
D
G
S
S
S
K
K
Q
M
V
F
G
Zebra Danio
Brachydanio rerio
NP_001014367
597
65855
K560
Y
M
S
D
G
S
P
K
M
R
Q
M
V
F
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_795930
531
58161
A499
Y
S
A
S
Q
T
V
A
Q
K
K
M
I
F
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P80608
325
34188
S308
F
G
E
R
Y
L
S
S
V
L
F
Q
S
I
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32582
507
56003
T488
K
N
S
S
A
V
I
T
D
G
L
K
P
I
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.2
N.A.
52.4
N.A.
82.5
82.3
N.A.
70.7
77.2
74.3
70.3
N.A.
N.A.
N.A.
N.A.
57.7
Protein Similarity:
100
92.5
N.A.
57.7
N.A.
88
88.9
N.A.
79.8
87.2
85.4
79.7
N.A.
N.A.
N.A.
N.A.
74.2
P-Site Identity:
100
100
N.A.
53.3
N.A.
60
46.6
N.A.
0
73.3
73.3
60
N.A.
N.A.
N.A.
N.A.
33.3
P-Site Similarity:
100
100
N.A.
66.6
N.A.
73.3
66.6
N.A.
46.6
86.6
86.6
60
N.A.
N.A.
N.A.
N.A.
73.3
Percent
Protein Identity:
N.A.
27.4
N.A.
N.A.
39.2
N.A.
Protein Similarity:
N.A.
38.4
N.A.
N.A.
55.9
N.A.
P-Site Identity:
N.A.
13.3
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
20
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
17
0
9
0
0
9
0
0
0
0
0
0
0
% A
% Cys:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
17
0
0
25
0
0
9
0
9
0
0
0
0
0
0
% D
% Glu:
0
0
9
0
9
0
0
0
0
0
0
0
9
0
0
% E
% Phe:
9
0
0
0
0
0
0
0
0
0
9
0
0
75
0
% F
% Gly:
0
9
9
0
59
0
0
0
0
9
0
0
0
0
67
% G
% His:
0
42
0
0
0
0
0
0
0
0
0
9
0
0
9
% H
% Ile:
0
0
0
0
0
0
9
0
0
0
0
0
9
17
0
% I
% Lys:
9
0
0
0
0
25
0
9
50
17
17
9
0
0
9
% K
% Leu:
0
0
0
0
0
9
0
0
0
9
17
0
0
0
0
% L
% Met:
0
9
0
0
0
9
0
0
9
0
0
67
0
0
0
% M
% Asn:
0
9
9
17
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
9
0
9
0
0
0
0
0
9
0
0
% P
% Gln:
0
0
0
0
9
0
0
0
25
25
59
9
0
0
0
% Q
% Arg:
9
9
0
9
0
9
0
0
0
42
0
0
0
0
9
% R
% Ser:
0
9
50
34
0
25
67
67
0
0
0
0
9
0
0
% S
% Thr:
0
9
9
17
0
9
0
17
0
0
0
9
0
9
0
% T
% Val:
0
0
0
0
0
17
9
0
9
0
0
0
67
0
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
50
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _