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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CBS
All Species:
27.58
Human Site:
S254
Identified Species:
55.15
UniProt:
P35520
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35520
NP_000062.1
551
60587
S254
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
Chimpanzee
Pan troglodytes
XP_001142443
593
64952
S254
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_853796
764
82787
S237
K
L
D
M
L
V
A
S
A
G
T
G
G
T
I
Cat
Felis silvestris
Mouse
Mus musculus
Q91WT9
561
61525
S251
K
L
D
M
L
V
A
S
A
G
T
G
G
T
I
Rat
Rattus norvegicus
P32232
561
61436
S251
K
V
D
M
L
V
A
S
A
G
T
G
G
T
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511742
606
66744
S254
K
L
D
M
L
V
A
S
A
G
T
G
G
T
I
Chicken
Gallus gallus
XP_416752
558
61762
T260
K
I
D
M
L
V
A
T
A
G
T
G
G
T
I
Frog
Xenopus laevis
NP_001086820
562
62067
G247
Q
L
D
M
L
V
A
G
A
G
T
G
G
T
I
Zebra Danio
Brachydanio rerio
NP_001014367
597
65855
G289
K
I
D
M
L
V
A
G
A
G
T
G
G
T
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_795930
531
58161
V235
G
A
G
T
G
G
T
V
T
G
I
G
R
K
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P80608
325
34188
V72
L
I
T
P
G
V
S
V
L
I
E
P
T
S
G
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32582
507
56003
T236
Q
P
E
N
L
N
K
T
D
I
T
D
Y
K
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.2
N.A.
52.4
N.A.
82.5
82.3
N.A.
70.7
77.2
74.3
70.3
N.A.
N.A.
N.A.
N.A.
57.7
Protein Similarity:
100
92.5
N.A.
57.7
N.A.
88
88.9
N.A.
79.8
87.2
85.4
79.7
N.A.
N.A.
N.A.
N.A.
74.2
P-Site Identity:
100
100
N.A.
93.3
N.A.
93.3
86.6
N.A.
93.3
80
80
80
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
100
N.A.
93.3
N.A.
93.3
93.3
N.A.
93.3
93.3
86.6
86.6
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
27.4
N.A.
N.A.
39.2
N.A.
Protein Similarity:
N.A.
38.4
N.A.
N.A.
55.9
N.A.
P-Site Identity:
N.A.
6.6
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
33.3
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
0
0
75
0
59
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
75
0
0
0
0
0
9
0
0
9
0
0
0
% D
% Glu:
0
0
9
0
0
0
0
0
0
0
9
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
9
0
9
0
17
9
0
17
0
84
0
84
75
0
9
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
25
0
0
0
0
0
0
0
17
9
0
0
0
75
% I
% Lys:
67
0
0
0
0
0
9
0
0
0
0
0
0
17
0
% K
% Leu:
9
50
0
0
84
0
0
0
9
0
0
0
0
0
9
% L
% Met:
0
0
0
75
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
9
0
9
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
9
0
9
0
0
0
0
0
0
0
9
0
0
0
% P
% Gln:
17
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% R
% Ser:
0
0
0
0
0
0
9
50
0
0
0
0
0
9
0
% S
% Thr:
0
0
9
9
0
0
9
17
9
0
84
0
9
75
0
% T
% Val:
0
9
0
0
0
84
0
17
17
0
0
0
0
0
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _