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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NF2 All Species: 47.88
Human Site: S265 Identified Species: 95.76
UniProt: P35240 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P35240 NP_000259.1 595 69690 S265 W N E I R N I S Y S D K E F T
Chimpanzee Pan troglodytes XP_001136298 595 69538 S265 W N E I R N I S Y S D K E Y M
Rhesus Macaque Macaca mulatta XP_001106489 595 69702 S265 W N E I R N I S Y S D K E F T
Dog Lupus familis XP_534729 596 69793 S265 W N E I R N I S Y S D K E F T
Cat Felis silvestris
Mouse Mus musculus P46662 596 69758 S265 W N E I R N I S Y S D K E F T
Rat Rattus norvegicus Q63648 586 68693 S261 W N E I R N I S Y S D K E F T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521866 636 73533 S258 W S G I R N I S Y S E R E L T
Chicken Gallus gallus Q9PU45 583 68536 S249 W S E I R N I S F N D K K F V
Frog Xenopus laevis NP_001086957 585 68810 S265 W N E I R N I S Y S D K E F T
Zebra Danio Brachydanio rerio NP_001122179 593 69546 S264 W N E I R N I S Y S D K E F A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24564 635 74474 S259 W N E I R H V S F D D K K F T
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_781142 608 70697 S275 W S E I R D I S F R D K K F T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 96.4 99.8 99.5 N.A. 98.3 95.1 N.A. 61.7 44.8 86.8 82.5 N.A. 47.4 N.A. N.A. 56.5
Protein Similarity: 100 97.6 99.8 99.5 N.A. 99.3 96.6 N.A. 76.5 65.5 92.7 91.2 N.A. 66.3 N.A. N.A. 75.4
P-Site Identity: 100 86.6 100 100 N.A. 100 100 N.A. 66.6 66.6 100 93.3 N.A. 66.6 N.A. N.A. 66.6
P-Site Similarity: 100 93.3 100 100 N.A. 100 100 N.A. 86.6 93.3 100 93.3 N.A. 93.3 N.A. N.A. 93.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 9 0 0 0 9 92 0 0 0 0 % D
% Glu: 0 0 92 0 0 0 0 0 0 0 9 0 75 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 25 0 0 0 0 84 0 % F
% Gly: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 100 0 0 92 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 92 25 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % M
% Asn: 0 75 0 0 0 84 0 0 0 9 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 100 0 0 0 0 9 0 9 0 0 0 % R
% Ser: 0 25 0 0 0 0 0 100 0 75 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 75 % T
% Val: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 9 % V
% Trp: 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 75 0 0 0 0 9 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _