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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOS2
All Species:
31.82
Human Site:
T403
Identified Species:
70
UniProt:
P35228
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35228
NP_000616.3
1153
131117
T403
G
R
R
M
G
L
E
T
H
K
L
A
S
L
W
Chimpanzee
Pan troglodytes
XP_001148238
1153
131137
T403
G
R
R
M
G
L
E
T
H
K
L
A
S
L
W
Rhesus Macaque
Macaca mulatta
XP_001106245
1153
130638
T403
G
R
R
M
G
L
E
T
H
K
L
A
S
L
W
Dog
Lupus familis
XP_534695
1431
160627
M620
A
K
K
M
N
L
D
M
R
K
T
S
S
L
W
Cat
Felis silvestris
Mouse
Mus musculus
P29477
1144
130557
T397
G
R
R
M
G
L
E
T
H
T
L
A
S
L
W
Rat
Rattus norvegicus
Q06518
1147
130609
T400
G
R
R
M
G
L
E
T
H
T
L
A
S
L
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506887
1152
131150
T411
G
R
R
M
G
L
D
T
H
K
T
A
S
L
W
Chicken
Gallus gallus
Q90703
1136
129631
S400
G
R
R
M
G
L
E
S
N
K
L
A
S
L
W
Frog
Xenopus laevis
NP_001079155
1419
160392
T608
A
L
K
M
N
L
D
T
R
K
T
S
S
L
W
Zebra Danio
Brachydanio rerio
NP_001098407
1079
121801
V368
Q
A
L
V
A
I
N
V
A
V
I
H
S
Y
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27571
1349
151696
T531
A
L
K
M
Q
L
D
T
R
T
P
T
S
L
W
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
97.1
45.7
N.A.
80.6
80.4
N.A.
73.2
69.3
44.8
55.5
N.A.
40.4
N.A.
N.A.
N.A.
Protein Similarity:
100
99.4
98.2
59
N.A.
88.4
87.8
N.A.
84.6
82
59.2
70.5
N.A.
54.9
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
40
N.A.
93.3
93.3
N.A.
86.6
86.6
46.6
6.6
N.A.
40
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
66.6
N.A.
93.3
93.3
N.A.
93.3
100
66.6
26.6
N.A.
53.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
28
10
0
0
10
0
0
0
10
0
0
64
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
37
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
55
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
64
0
0
0
64
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
55
0
0
10
0
0
0
% H
% Ile:
0
0
0
0
0
10
0
0
0
0
10
0
0
0
0
% I
% Lys:
0
10
28
0
0
0
0
0
0
64
0
0
0
0
0
% K
% Leu:
0
19
10
0
0
91
0
0
0
0
55
0
0
91
0
% L
% Met:
0
0
0
91
0
0
0
10
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
19
0
10
0
10
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% P
% Gln:
10
0
0
0
10
0
0
0
0
0
0
0
0
0
10
% Q
% Arg:
0
64
64
0
0
0
0
0
28
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
10
0
0
0
19
100
0
0
% S
% Thr:
0
0
0
0
0
0
0
73
0
28
28
10
0
0
0
% T
% Val:
0
0
0
10
0
0
0
10
0
10
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
91
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _