KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TRHR
All Species:
32.73
Human Site:
S225
Identified Species:
60
UniProt:
P34981
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P34981
NP_003292.1
398
45085
S225
L
F
L
N
P
I
P
S
D
P
K
E
N
S
K
Chimpanzee
Pan troglodytes
XP_528214
398
45052
S225
L
F
L
N
P
I
P
S
D
P
K
E
N
S
K
Rhesus Macaque
Macaca mulatta
XP_001091307
398
45052
S225
L
F
L
N
P
I
P
S
D
P
K
E
N
S
K
Dog
Lupus familis
XP_539128
398
45121
S225
L
F
L
N
P
I
P
S
D
P
K
E
N
S
K
Cat
Felis silvestris
Mouse
Mus musculus
P21761
393
44541
S225
L
F
L
N
P
I
P
S
D
P
K
E
N
S
K
Rat
Rattus norvegicus
Q01717
412
46590
S225
L
F
L
N
P
I
P
S
D
P
K
E
N
S
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516760
263
29638
G97
S
W
V
Y
G
Y
A
G
C
L
C
I
T
Y
L
Chicken
Gallus gallus
O93603
395
44679
S227
L
F
L
N
P
I
P
S
D
P
K
E
N
S
N
Frog
Xenopus laevis
O42574
385
43291
L215
I
I
S
F
Y
F
P
L
I
I
M
I
F
V
Y
Zebra Danio
Brachydanio rerio
NP_001108160
399
44922
S222
L
F
L
N
P
L
P
S
D
T
K
E
E
K
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q8ITC7
477
53986
S269
R
M
G
A
K
I
R
S
R
T
N
Q
K
L
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_491990
395
43984
T224
I
Y
A
K
I
G
I
T
L
S
Q
C
G
D
K
Sea Urchin
Strong. purpuratus
XP_783972
427
47637
M255
R
V
L
F
R
S
T
M
S
Q
N
G
I
R
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.2
97.4
N.A.
93.2
91.2
N.A.
58
81.4
27.3
64.9
N.A.
24.3
N.A.
35.4
40.9
Protein Similarity:
100
100
99.7
98.9
N.A.
96.7
93.9
N.A.
62.3
89.1
48.2
78.6
N.A.
42.3
N.A.
59.7
58.5
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
0
93.3
6.6
66.6
N.A.
13.3
N.A.
6.6
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
13.3
93.3
13.3
73.3
N.A.
20
N.A.
33.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
8
0
0
8
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
8
8
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
62
0
0
0
0
8
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
62
8
0
0
% E
% Phe:
0
62
0
16
0
8
0
0
0
0
0
0
8
0
0
% F
% Gly:
0
0
8
0
8
8
0
8
0
0
0
8
8
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
16
8
0
0
8
62
8
0
8
8
0
16
8
0
0
% I
% Lys:
0
0
0
8
8
0
0
0
0
0
62
0
8
8
54
% K
% Leu:
62
0
70
0
0
8
0
8
8
8
0
0
0
8
8
% L
% Met:
0
8
0
0
0
0
0
8
0
0
8
0
0
0
0
% M
% Asn:
0
0
0
62
0
0
0
0
0
0
16
0
54
0
16
% N
% Pro:
0
0
0
0
62
0
70
0
0
54
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
8
8
8
0
0
0
% Q
% Arg:
16
0
0
0
8
0
8
0
8
0
0
0
0
8
8
% R
% Ser:
8
0
8
0
0
8
0
70
8
8
0
0
0
54
0
% S
% Thr:
0
0
0
0
0
0
8
8
0
16
0
0
8
0
0
% T
% Val:
0
8
8
0
0
0
0
0
0
0
0
0
0
8
0
% V
% Trp:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
8
8
8
0
0
0
0
0
0
0
8
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _