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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SHMT2
All Species:
31.82
Human Site:
T420
Identified Species:
53.85
UniProt:
P34897
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.31
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P34897
NP_005403.2
504
55993
T420
P
G
D
R
S
A
I
T
P
G
G
L
R
L
G
Chimpanzee
Pan troglodytes
XP_509157
506
56077
T420
P
G
D
R
S
A
I
T
P
G
G
L
R
L
G
Rhesus Macaque
Macaca mulatta
XP_001115892
509
56717
T425
P
G
D
R
S
A
I
T
P
G
G
L
R
L
G
Dog
Lupus familis
XP_849244
505
56202
T421
P
G
D
R
S
A
I
T
P
G
G
L
R
L
G
Cat
Felis silvestris
Mouse
Mus musculus
P50431
478
52566
R391
P
G
D
K
S
A
L
R
P
S
G
L
R
L
G
Rat
Rattus norvegicus
NP_001008323
504
55746
T420
P
G
D
R
S
A
I
T
P
G
G
L
R
L
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510083
484
53208
R397
P
G
D
K
S
A
L
R
P
S
G
L
R
L
G
Chicken
Gallus gallus
XP_414824
580
63427
R494
P
G
D
V
S
A
L
R
P
S
G
L
R
F
G
Frog
Xenopus laevis
NP_001087369
496
54903
T412
P
G
D
K
S
A
L
T
P
G
G
L
R
L
G
Zebra Danio
Brachydanio rerio
NP_001116846
492
54420
T408
P
G
D
K
S
A
L
T
P
G
G
L
R
L
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P50432
507
55746
R422
P
G
D
V
S
A
L
R
P
G
G
I
R
L
G
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SZJ5
517
57382
V425
P
G
D
V
S
A
M
V
P
G
G
I
R
M
G
Baker's Yeast
Sacchar. cerevisiae
P37291
469
52200
V388
P
G
D
K
S
A
L
V
P
G
G
V
R
I
G
Red Bread Mold
Neurospora crassa
P34898
480
52959
T389
P
G
D
K
S
A
L
T
P
G
G
L
R
I
G
Conservation
Percent
Protein Identity:
100
98.8
94.1
95
N.A.
60.7
93.8
N.A.
60.5
54.1
80.9
76.1
N.A.
N.A.
N.A.
55.8
N.A.
Protein Similarity:
100
99
95.6
97.4
N.A.
74
96
N.A.
75.1
66.3
91.4
86.9
N.A.
N.A.
N.A.
73.1
N.A.
P-Site Identity:
100
100
100
100
N.A.
73.3
100
N.A.
73.3
66.6
86.6
86.6
N.A.
N.A.
N.A.
73.3
N.A.
P-Site Similarity:
100
100
100
100
N.A.
86.6
100
N.A.
86.6
73.3
100
100
N.A.
N.A.
N.A.
86.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
56.8
50.7
53.5
Protein Similarity:
N.A.
N.A.
N.A.
72.3
68.8
70.4
P-Site Identity:
N.A.
N.A.
N.A.
66.6
66.6
80
P-Site Similarity:
N.A.
N.A.
N.A.
86.6
93.3
100
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
100
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
100
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% F
% Gly:
0
100
0
0
0
0
0
0
0
79
100
0
0
0
100
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
36
0
0
0
0
15
0
15
0
% I
% Lys:
0
0
0
43
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
58
0
0
0
0
79
0
72
0
% L
% Met:
0
0
0
0
0
0
8
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
100
0
0
0
0
0
0
0
100
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
36
0
0
0
29
0
0
0
0
100
0
0
% R
% Ser:
0
0
0
0
100
0
0
0
0
22
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
58
0
0
0
0
0
0
0
% T
% Val:
0
0
0
22
0
0
0
15
0
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _