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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SHMT2
All Species:
26.67
Human Site:
S470
Identified Species:
45.13
UniProt:
P34897
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P34897
NP_005403.2
504
55993
S470
A
K
L
Q
D
F
K
S
F
L
L
K
D
S
E
Chimpanzee
Pan troglodytes
XP_509157
506
56077
S470
A
K
L
Q
D
F
K
S
F
L
L
K
D
S
E
Rhesus Macaque
Macaca mulatta
XP_001115892
509
56717
S475
A
K
L
Q
D
F
K
S
F
L
L
K
D
S
E
Dog
Lupus familis
XP_849244
505
56202
S471
A
K
L
Q
D
F
K
S
F
L
L
K
D
S
E
Cat
Felis silvestris
Mouse
Mus musculus
P50431
478
52566
E441
A
T
K
A
T
L
K
E
F
K
E
K
L
A
G
Rat
Rattus norvegicus
NP_001008323
504
55746
S470
A
K
L
Q
D
F
K
S
F
L
L
K
D
P
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510083
484
53208
E450
A
T
L
K
E
F
K
E
R
L
A
G
D
E
K
Chicken
Gallus gallus
XP_414824
580
63427
A540
Q
K
D
M
N
P
K
A
T
L
K
E
F
K
E
Frog
Xenopus laevis
NP_001087369
496
54903
N462
N
K
L
Q
D
F
K
N
F
L
L
E
D
Q
E
Zebra Danio
Brachydanio rerio
NP_001116846
492
54420
S458
K
K
L
S
D
F
K
S
F
L
L
E
D
A
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P50432
507
55746
S473
K
T
L
K
D
F
K
S
F
T
E
T
N
E
P
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SZJ5
517
57382
S477
T
K
L
K
D
F
V
S
A
M
E
S
S
S
T
Baker's Yeast
Sacchar. cerevisiae
P37291
469
52200
A442
C
R
L
K
D
F
K
A
K
V
D
E
G
S
D
Red Bread Mold
Neurospora crassa
P34898
480
52959
A435
Q
A
S
L
P
K
E
A
N
K
Q
K
D
F
K
Conservation
Percent
Protein Identity:
100
98.8
94.1
95
N.A.
60.7
93.8
N.A.
60.5
54.1
80.9
76.1
N.A.
N.A.
N.A.
55.8
N.A.
Protein Similarity:
100
99
95.6
97.4
N.A.
74
96
N.A.
75.1
66.3
91.4
86.9
N.A.
N.A.
N.A.
73.1
N.A.
P-Site Identity:
100
100
100
100
N.A.
26.6
93.3
N.A.
40
26.6
73.3
73.3
N.A.
N.A.
N.A.
40
N.A.
P-Site Similarity:
100
100
100
100
N.A.
33.3
93.3
N.A.
60
46.6
86.6
86.6
N.A.
N.A.
N.A.
53.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
56.8
50.7
53.5
Protein Similarity:
N.A.
N.A.
N.A.
72.3
68.8
70.4
P-Site Identity:
N.A.
N.A.
N.A.
40
33.3
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
53.3
73.3
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
50
8
0
8
0
0
0
22
8
0
8
0
0
15
0
% A
% Cys:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
72
0
0
0
0
0
8
0
65
0
8
% D
% Glu:
0
0
0
0
8
0
8
15
0
0
22
29
0
15
58
% E
% Phe:
0
0
0
0
0
79
0
0
65
0
0
0
8
8
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
8
8
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
15
65
8
29
0
8
86
0
8
15
8
50
0
8
15
% K
% Leu:
0
0
79
8
0
8
0
0
0
65
50
0
8
0
0
% L
% Met:
0
0
0
8
0
0
0
0
0
8
0
0
0
0
0
% M
% Asn:
8
0
0
0
8
0
0
8
8
0
0
0
8
0
0
% N
% Pro:
0
0
0
0
8
8
0
0
0
0
0
0
0
8
8
% P
% Gln:
15
0
0
43
0
0
0
0
0
0
8
0
0
8
0
% Q
% Arg:
0
8
0
0
0
0
0
0
8
0
0
0
0
0
0
% R
% Ser:
0
0
8
8
0
0
0
58
0
0
0
8
8
43
0
% S
% Thr:
8
22
0
0
8
0
0
0
8
8
0
8
0
0
8
% T
% Val:
0
0
0
0
0
0
8
0
0
8
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _