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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SHMT1
All Species:
18.18
Human Site:
S41
Identified Species:
30.77
UniProt:
P34896
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.31
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P34896
NP_004160.3
483
53083
S41
Y
N
I
I
K
K
E
S
N
R
Q
R
V
G
L
Chimpanzee
Pan troglodytes
XP_511325
483
53092
S41
Y
N
I
I
K
K
E
S
N
R
Q
R
V
G
L
Rhesus Macaque
Macaca mulatta
XP_001096193
483
53122
S41
Y
N
I
I
K
K
E
S
N
R
Q
R
V
G
L
Dog
Lupus familis
XP_851819
483
53313
V45
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
Cat
Felis silvestris
Mouse
Mus musculus
P50431
478
52566
G41
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
Rat
Rattus norvegicus
NP_001041307
681
75356
S238
Y
S
I
I
K
K
E
S
N
R
Q
R
V
G
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510083
484
53208
S41
Y
S
I
I
K
K
E
S
H
R
Q
K
V
G
L
Chicken
Gallus gallus
XP_414824
580
63427
K138
Y
N
I
I
K
K
E
K
Q
R
Q
R
L
G
L
Frog
Xenopus laevis
NP_001080356
485
53733
K42
Y
E
I
I
R
K
E
K
H
R
Q
R
Y
G
L
Zebra Danio
Brachydanio rerio
NP_957340
481
53365
Q41
I
K
K
E
K
K
R
Q
T
Y
G
L
E
L
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P50432
507
55746
K67
F
D
I
M
K
N
E
K
K
R
Q
R
R
G
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SZJ5
517
57382
K70
A
D
I
I
E
H
E
K
A
R
Q
W
K
G
L
Baker's Yeast
Sacchar. cerevisiae
P37291
469
52200
L41
R
Q
K
H
S
I
D
L
I
A
S
E
N
F
T
Red Bread Mold
Neurospora crassa
P34898
480
52959
I41
Q
R
Q
R
E
S
I
I
L
I
A
S
E
N
V
Conservation
Percent
Protein Identity:
100
99.7
98.1
91.3
N.A.
90.2
65
N.A.
87.5
67.9
78.9
78.8
N.A.
N.A.
N.A.
57.9
N.A.
Protein Similarity:
100
99.7
98.5
96
N.A.
94.1
68.1
N.A.
94
75.3
87.2
88.8
N.A.
N.A.
N.A.
73.1
N.A.
P-Site Identity:
100
100
100
0
N.A.
0
93.3
N.A.
80
80
66.6
13.3
N.A.
N.A.
N.A.
53.3
N.A.
P-Site Similarity:
100
100
100
26.6
N.A.
20
100
N.A.
100
86.6
80
20
N.A.
N.A.
N.A.
73.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
54.7
53.6
56.9
Protein Similarity:
N.A.
N.A.
N.A.
70.6
72.4
73
P-Site Identity:
N.A.
N.A.
N.A.
46.6
0
0
P-Site Similarity:
N.A.
N.A.
N.A.
60
6.6
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
0
0
8
8
8
0
8
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
15
0
0
0
0
8
0
0
0
0
0
0
0
0
% D
% Glu:
8
15
0
8
15
0
65
0
0
8
8
8
15
0
8
% E
% Phe:
8
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% F
% Gly:
0
0
0
0
0
0
0
8
8
0
8
0
0
65
0
% G
% His:
0
0
0
8
0
8
0
0
15
0
0
0
0
0
0
% H
% Ile:
8
0
65
58
0
8
8
8
8
8
0
8
8
0
8
% I
% Lys:
8
8
15
0
58
58
0
29
8
0
0
8
8
0
0
% K
% Leu:
0
0
0
0
0
0
0
8
15
8
8
15
8
8
65
% L
% Met:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
29
8
8
0
8
0
0
29
0
0
0
8
8
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
8
8
8
0
8
8
0
8
8
0
65
0
0
0
0
% Q
% Arg:
8
8
0
15
15
8
15
0
0
65
0
50
8
0
0
% R
% Ser:
0
22
8
0
8
8
0
36
0
0
8
8
0
8
8
% S
% Thr:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
8
% T
% Val:
0
0
0
0
0
0
8
8
0
0
0
0
36
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% W
% Tyr:
50
0
0
0
0
0
0
0
0
8
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _