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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CYP2C18
All Species:
16.67
Human Site:
S336
Identified Species:
61.11
UniProt:
P33260
Number Species:
6
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33260
NP_000763.1
490
55711
S336
C
V
V
G
R
N
R
S
P
C
M
Q
D
R
S
Chimpanzee
Pan troglodytes
XP_001152531
490
55771
S336
R
V
I
G
R
N
R
S
P
C
M
Q
D
R
S
Rhesus Macaque
Macaca mulatta
Q6GUQ4
493
56626
I338
R
V
I
G
P
S
R
I
P
A
I
K
D
R
Q
Dog
Lupus familis
XP_534973
490
55872
S336
R
V
V
G
R
H
R
S
P
C
M
Q
D
R
S
Cat
Felis silvestris
Mouse
Mus musculus
Q64458
490
55711
S336
R
V
V
G
R
H
R
S
P
C
M
Q
D
R
S
Rat
Rattus norvegicus
P33273
490
55972
R336
H
V
I
G
R
H
R
R
P
C
M
Q
D
R
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P20678
491
56467
S337
R
V
V
G
R
D
R
S
P
C
M
A
D
R
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
83.4
57.2
69.3
N.A.
76.5
77.9
N.A.
N.A.
57.4
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
92.4
75.2
84.2
N.A.
88.9
90
N.A.
N.A.
74.7
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
86.6
40
86.6
N.A.
86.6
66.6
N.A.
N.A.
80
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
93.3
66.6
93.3
N.A.
93.3
86.6
N.A.
N.A.
86.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
15
0
15
0
0
0
% A
% Cys:
15
0
0
0
0
0
0
0
0
86
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
15
0
0
0
0
0
0
100
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
100
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
15
0
0
0
0
43
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
43
0
0
0
0
15
0
0
15
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
15
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
86
0
0
0
0
% M
% Asn:
0
0
0
0
0
29
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
15
0
0
0
100
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
72
0
0
15
% Q
% Arg:
72
0
0
0
86
0
100
15
0
0
0
0
0
100
0
% R
% Ser:
0
0
0
0
0
15
0
72
0
0
0
0
0
0
72
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
15
% T
% Val:
0
100
58
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _