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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GRK4
All Species:
12.42
Human Site:
Y389
Identified Species:
27.33
UniProt:
P32298
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.5
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P32298
NP_001004056.1
578
66583
Y389
G
H
S
P
F
K
K
Y
K
E
K
V
K
W
E
Chimpanzee
Pan troglodytes
XP_001152424
578
66563
Y389
G
H
S
P
F
K
K
Y
K
E
K
V
K
W
E
Rhesus Macaque
Macaca mulatta
XP_001090350
576
66059
R388
G
Q
S
P
F
Q
Q
R
K
K
K
I
K
R
E
Dog
Lupus familis
XP_536222
561
65158
F373
G
H
S
P
F
R
K
F
K
E
K
V
K
R
E
Cat
Felis silvestris
Mouse
Mus musculus
O70291
574
66894
Y388
G
H
S
P
F
R
K
Y
K
E
K
V
N
R
E
Rat
Rattus norvegicus
P70507
575
66769
Y388
G
H
S
P
F
R
K
Y
K
E
K
V
N
R
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001006459
569
65676
H385
G
Q
S
P
F
R
K
H
K
E
R
V
K
R
D
Frog
Xenopus laevis
NP_001086996
575
66549
R388
G
Q
S
P
F
R
K
R
K
E
K
V
K
R
D
Zebra Danio
Brachydanio rerio
NP_001073455
573
65930
R388
G
Q
S
P
F
R
R
R
K
E
R
V
K
R
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P32866
714
80668
R512
G
Q
A
P
F
R
M
R
K
E
K
V
K
R
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09537
642
73759
R405
G
K
A
P
F
R
Q
R
K
E
K
V
K
R
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
65.5
76.4
N.A.
75.2
75.4
N.A.
N.A.
74.2
75.4
73.8
N.A.
49
N.A.
50.7
N.A.
Protein Similarity:
100
99.6
78.1
84.5
N.A.
86.3
87
N.A.
N.A.
85.1
86.3
84.2
N.A.
60.6
N.A.
66
N.A.
P-Site Identity:
100
100
53.3
80
N.A.
80
80
N.A.
N.A.
60
66.6
60
N.A.
60
N.A.
60
N.A.
P-Site Similarity:
100
100
80
93.3
N.A.
86.6
86.6
N.A.
N.A.
86.6
80
80
N.A.
73.3
N.A.
80
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
19
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
19
% D
% Glu:
0
0
0
0
0
0
0
0
0
91
0
0
0
0
82
% E
% Phe:
0
0
0
0
100
0
0
10
0
0
0
0
0
0
0
% F
% Gly:
100
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
46
0
0
0
0
0
10
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% I
% Lys:
0
10
0
0
0
19
64
0
100
10
82
0
82
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
19
0
0
% N
% Pro:
0
0
0
100
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
46
0
0
0
10
19
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
73
10
46
0
0
19
0
0
82
0
% R
% Ser:
0
0
82
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
91
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
19
0
% W
% Tyr:
0
0
0
0
0
0
0
37
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _