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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
WEE1
All Species:
18.79
Human Site:
S248
Identified Species:
31.79
UniProt:
P30291
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P30291
NP_003381.1
646
71597
S248
D
S
L
L
L
H
S
S
G
Q
C
R
R
R
K
Chimpanzee
Pan troglodytes
XP_521839
646
71607
S248
D
S
L
L
L
H
S
S
G
Q
C
R
R
R
K
Rhesus Macaque
Macaca mulatta
NP_001099016
568
63102
T203
K
R
C
V
L
R
E
T
N
M
A
S
R
Y
E
Dog
Lupus familis
XP_534051
887
95991
S489
D
S
V
L
L
H
S
S
G
Q
C
R
R
R
K
Cat
Felis silvestris
Mouse
Mus musculus
P47810
646
71560
S247
P
D
P
V
L
L
H
S
S
G
R
C
R
G
R
Rat
Rattus norvegicus
Q63802
646
71478
S248
D
P
V
M
L
H
S
S
G
Q
C
R
G
R
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510171
572
63943
A207
E
D
E
A
T
R
P
A
K
R
I
T
I
T
E
Chicken
Gallus gallus
NP_001026352
641
70947
R244
M
F
L
H
N
S
E
R
Q
C
R
R
R
K
R
Frog
Xenopus laevis
P47817
555
61670
V189
A
E
K
E
H
P
A
V
F
Q
S
K
R
F
V
Zebra Danio
Brachydanio rerio
NP_001005770
612
68517
S235
C
G
E
D
M
D
A
S
D
A
E
I
E
D
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P54350
609
68790
K236
D
T
N
I
S
R
F
K
R
E
F
M
Q
V
N
Honey Bee
Apis mellifera
XP_624069
589
66032
S224
K
R
V
A
L
Q
D
S
N
I
L
R
Y
H
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999796
624
68925
I243
R
L
R
Q
E
R
S
I
L
D
D
D
E
D
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8L4H0
500
56512
V135
S
P
V
K
L
N
T
V
K
S
K
R
C
R
Q
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
42.1
70.9
N.A.
90.5
91.6
N.A.
72.7
80.1
42.8
64.2
N.A.
36.5
41.6
N.A.
39.6
Protein Similarity:
100
99.8
56.1
71.3
N.A.
92.7
93.1
N.A.
79.2
85.9
55.2
75
N.A.
54.1
59.2
N.A.
55.5
P-Site Identity:
100
100
13.3
93.3
N.A.
20
73.3
N.A.
0
20
13.3
6.6
N.A.
6.6
20
N.A.
6.6
P-Site Similarity:
100
100
33.3
100
N.A.
33.3
86.6
N.A.
26.6
33.3
26.6
26.6
N.A.
33.3
33.3
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
23
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.8
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
15
0
0
15
8
0
8
8
0
0
0
0
% A
% Cys:
8
0
8
0
0
0
0
0
0
8
29
8
8
0
0
% C
% Asp:
36
15
0
8
0
8
8
0
8
8
8
8
0
15
0
% D
% Glu:
8
8
15
8
8
0
15
0
0
8
8
0
15
0
22
% E
% Phe:
0
8
0
0
0
0
8
0
8
0
8
0
0
8
0
% F
% Gly:
0
8
0
0
0
0
0
0
29
8
0
0
8
8
0
% G
% His:
0
0
0
8
8
29
8
0
0
0
0
0
0
8
0
% H
% Ile:
0
0
0
8
0
0
0
8
0
8
8
8
8
0
0
% I
% Lys:
15
0
8
8
0
0
0
8
15
0
8
8
0
8
29
% K
% Leu:
0
8
22
22
58
8
0
0
8
0
8
0
0
0
8
% L
% Met:
8
0
0
8
8
0
0
0
0
8
0
8
0
0
0
% M
% Asn:
0
0
8
0
8
8
0
0
15
0
0
0
0
0
8
% N
% Pro:
8
15
8
0
0
8
8
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
8
0
8
0
0
8
36
0
0
8
0
15
% Q
% Arg:
8
15
8
0
0
29
0
8
8
8
15
50
50
36
15
% R
% Ser:
8
22
0
0
8
8
36
50
8
8
8
8
0
0
0
% S
% Thr:
0
8
0
0
8
0
8
8
0
0
0
8
0
8
0
% T
% Val:
0
0
29
15
0
0
0
15
0
0
0
0
0
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
8
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _