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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
WEE1
All Species:
15.45
Human Site:
S139
Identified Species:
26.15
UniProt:
P30291
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P30291
NP_003381.1
646
71597
S139
Y
F
L
G
S
S
F
S
P
V
R
C
G
G
P
Chimpanzee
Pan troglodytes
XP_521839
646
71607
S139
Y
F
L
G
S
S
F
S
P
V
R
C
G
G
P
Rhesus Macaque
Macaca mulatta
NP_001099016
568
63102
T94
H
P
L
K
C
P
E
T
P
A
Q
E
D
S
R
Dog
Lupus familis
XP_534051
887
95991
S380
Y
F
L
G
S
S
F
S
P
V
R
C
G
G
A
Cat
Felis silvestris
Mouse
Mus musculus
P47810
646
71560
F138
A
Y
F
L
S
S
P
F
S
P
V
R
C
G
G
Rat
Rattus norvegicus
Q63802
646
71478
S139
Y
F
L
G
S
S
F
S
P
V
R
C
G
G
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510171
572
63943
T98
P
V
P
D
Y
P
G
T
P
P
H
K
T
F
R
Chicken
Gallus gallus
NP_001026352
641
70947
R135
P
P
P
P
H
K
G
R
R
S
A
G
R
S
P
Frog
Xenopus laevis
P47817
555
61670
G80
Y
S
P
D
P
S
V
G
A
E
C
P
G
T
P
Zebra Danio
Brachydanio rerio
NP_001005770
612
68517
E126
S
Y
I
H
D
D
M
E
G
C
S
S
P
I
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P54350
609
68790
V127
L
S
A
A
A
A
A
V
N
A
S
R
R
S
D
Honey Bee
Apis mellifera
XP_624069
589
66032
A115
P
P
Y
K
R
V
R
A
L
R
L
F
D
S
P
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999796
624
68925
R134
G
S
P
P
P
H
K
R
L
R
N
L
K
L
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8L4H0
500
56512
K26
I
K
T
R
A
S
K
K
I
R
K
M
E
G
T
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
42.1
70.9
N.A.
90.5
91.6
N.A.
72.7
80.1
42.8
64.2
N.A.
36.5
41.6
N.A.
39.6
Protein Similarity:
100
99.8
56.1
71.3
N.A.
92.7
93.1
N.A.
79.2
85.9
55.2
75
N.A.
54.1
59.2
N.A.
55.5
P-Site Identity:
100
100
13.3
93.3
N.A.
20
100
N.A.
6.6
6.6
26.6
6.6
N.A.
0
6.6
N.A.
0
P-Site Similarity:
100
100
33.3
93.3
N.A.
26.6
100
N.A.
13.3
6.6
26.6
20
N.A.
13.3
13.3
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
23
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.8
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
8
15
8
8
8
8
15
8
0
0
0
8
% A
% Cys:
0
0
0
0
8
0
0
0
0
8
8
29
8
0
0
% C
% Asp:
0
0
0
15
8
8
0
0
0
0
0
0
15
0
8
% D
% Glu:
0
0
0
0
0
0
8
8
0
8
0
8
8
0
0
% E
% Phe:
0
29
8
0
0
0
29
8
0
0
0
8
0
8
8
% F
% Gly:
8
0
0
29
0
0
15
8
8
0
0
8
36
43
8
% G
% His:
8
0
0
8
8
8
0
0
0
0
8
0
0
0
0
% H
% Ile:
8
0
8
0
0
0
0
0
8
0
0
0
0
8
0
% I
% Lys:
0
8
0
15
0
8
15
8
0
0
8
8
8
0
0
% K
% Leu:
8
0
36
8
0
0
0
0
15
0
8
8
0
8
0
% L
% Met:
0
0
0
0
0
0
8
0
0
0
0
8
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
8
0
8
0
0
0
0
% N
% Pro:
22
22
29
15
15
15
8
0
43
15
0
8
8
0
50
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% Q
% Arg:
0
0
0
8
8
0
8
15
8
22
29
15
15
0
15
% R
% Ser:
8
22
0
0
36
50
0
29
8
8
15
8
0
29
0
% S
% Thr:
0
0
8
0
0
0
0
15
0
0
0
0
8
8
8
% T
% Val:
0
8
0
0
0
8
8
8
0
29
8
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
36
15
8
0
8
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _