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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: WEE1 All Species: 18.48
Human Site: S123 Identified Species: 31.28
UniProt: P30291 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P30291 NP_003381.1 646 71597 S123 E E G F G S S S P V K S P A A
Chimpanzee Pan troglodytes XP_521839 646 71607 S123 E E G F G S S S P V K S P A A
Rhesus Macaque Macaca mulatta NP_001099016 568 63102 D78 E K D N E S P D Q I L R T P V
Dog Lupus familis XP_534051 887 95991 S364 E E G F G S S S P V K S P A A
Cat Felis silvestris
Mouse Mus musculus P47810 646 71560 S122 E E E G F G S S S P V K S P S
Rat Rattus norvegicus Q63802 646 71478 S123 E E G F G S S S P V K S P T T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510171 572 63943 R82 G D A S P R A R P P P D A S A
Chicken Gallus gallus NP_001026352 641 70947 A119 S P V K S P G A Y F T A G S P
Frog Xenopus laevis P47817 555 61670 T64 N E R E L S P T Q E L S P S S
Zebra Danio Brachydanio rerio NP_001005770 612 68517 P110 P S P R K S P P A Y D S S P E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P54350 609 68790 K111 T P K T I L Q K S T T Q C S N
Honey Bee Apis mellifera XP_624069 589 66032 S99 P P R E N I C S Q K I S M A C
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus NP_999796 624 68925 S118 V C A S S P A S S A G G G D A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8L4H0 500 56512 L10 E K N G R T L L A K R K T Q G
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 42.1 70.9 N.A. 90.5 91.6 N.A. 72.7 80.1 42.8 64.2 N.A. 36.5 41.6 N.A. 39.6
Protein Similarity: 100 99.8 56.1 71.3 N.A. 92.7 93.1 N.A. 79.2 85.9 55.2 75 N.A. 54.1 59.2 N.A. 55.5
P-Site Identity: 100 100 13.3 100 N.A. 26.6 86.6 N.A. 13.3 0 26.6 13.3 N.A. 0 20 N.A. 13.3
P-Site Similarity: 100 100 26.6 100 N.A. 33.3 86.6 N.A. 33.3 20 46.6 13.3 N.A. 6.6 20 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. 23 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 38.8 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 15 0 0 0 15 8 15 8 0 8 8 29 36 % A
% Cys: 0 8 0 0 0 0 8 0 0 0 0 0 8 0 8 % C
% Asp: 0 8 8 0 0 0 0 8 0 0 8 8 0 8 0 % D
% Glu: 50 43 8 15 8 0 0 0 0 8 0 0 0 0 8 % E
% Phe: 0 0 0 29 8 0 0 0 0 8 0 0 0 0 0 % F
% Gly: 8 0 29 15 29 8 8 0 0 0 8 8 15 0 8 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 8 8 0 0 0 8 8 0 0 0 0 % I
% Lys: 0 15 8 8 8 0 0 8 0 15 29 15 0 0 0 % K
% Leu: 0 0 0 0 8 8 8 8 0 0 15 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % M
% Asn: 8 0 8 8 8 0 0 0 0 0 0 0 0 0 8 % N
% Pro: 15 22 8 0 8 15 22 8 36 15 8 0 36 22 8 % P
% Gln: 0 0 0 0 0 0 8 0 22 0 0 8 0 8 0 % Q
% Arg: 0 0 15 8 8 8 0 8 0 0 8 8 0 0 0 % R
% Ser: 8 8 0 15 15 50 36 50 22 0 0 50 15 29 15 % S
% Thr: 8 0 0 8 0 8 0 8 0 8 15 0 15 8 8 % T
% Val: 8 0 8 0 0 0 0 0 0 29 8 0 0 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 8 8 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _