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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TKT
All Species:
20.91
Human Site:
S548
Identified Species:
35.38
UniProt:
P29401
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P29401
NP_001055.1
623
67878
S548
D
R
K
L
I
L
D
S
A
R
A
T
K
G
R
Chimpanzee
Pan troglodytes
Q5R1W6
623
67821
S548
D
R
K
L
I
L
D
S
A
R
A
T
K
G
R
Rhesus Macaque
Macaca mulatta
XP_001095403
703
76522
S629
D
A
A
T
I
I
S
S
A
K
A
T
G
G
R
Dog
Lupus familis
XP_533792
619
67627
S544
D
R
N
L
I
L
E
S
A
R
A
T
K
G
R
Cat
Felis silvestris
Mouse
Mus musculus
P40142
623
67612
S548
D
R
K
L
I
L
D
S
A
R
A
T
K
G
R
Rat
Rattus norvegicus
P50137
623
67625
C548
D
K
K
L
I
L
D
C
A
R
A
T
K
G
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508404
725
77819
S650
D
K
K
L
I
L
D
S
A
K
A
T
K
G
R
Chicken
Gallus gallus
XP_414333
627
68436
N548
D
K
K
T
I
L
E
N
A
R
A
T
K
G
R
Frog
Xenopus laevis
NP_001083312
627
67992
N548
D
K
K
T
I
V
E
N
A
K
A
T
N
G
H
Zebra Danio
Brachydanio rerio
XP_685690
628
69366
H549
D
N
K
T
I
V
D
H
V
R
A
T
R
G
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623357
627
67899
N553
D
A
Q
L
I
V
K
N
A
K
E
V
G
G
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001177524
625
66606
C552
D
A
A
T
L
T
A
C
A
K
A
A
G
G
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q7SIC9
675
72975
D603
F
V
S
W
E
L
F
D
E
Q
S
D
E
Y
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P23254
680
73787
E616
N
V
P
I
M
S
V
E
V
L
A
T
T
C
W
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
61.1
87.3
N.A.
94.6
94
N.A.
74.6
84.2
78.3
71
N.A.
N.A.
62.2
N.A.
61.1
Protein Similarity:
100
99.6
72.2
91.8
N.A.
97.9
97.7
N.A.
81.2
92.3
90.4
84.5
N.A.
N.A.
76.2
N.A.
76.3
P-Site Identity:
100
100
53.3
86.6
N.A.
100
86.6
N.A.
86.6
73.3
46.6
60
N.A.
N.A.
40
N.A.
33.3
P-Site Similarity:
100
100
66.6
93.3
N.A.
100
93.3
N.A.
100
93.3
80
73.3
N.A.
N.A.
66.6
N.A.
46.6
Percent
Protein Identity:
N.A.
25.3
N.A.
N.A.
25.4
N.A.
Protein Similarity:
N.A.
42.3
N.A.
N.A.
41.1
N.A.
P-Site Identity:
N.A.
6.6
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
33.3
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
22
15
0
0
0
8
0
79
0
86
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
15
0
0
0
0
0
8
0
% C
% Asp:
86
0
0
0
0
0
43
8
0
0
0
8
0
0
0
% D
% Glu:
0
0
0
0
8
0
22
8
8
0
8
0
8
0
0
% E
% Phe:
8
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
22
86
0
% G
% His:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
8
% H
% Ile:
0
0
0
8
79
8
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
29
58
0
0
0
8
0
0
36
0
0
50
0
8
% K
% Leu:
0
0
0
50
8
58
0
0
0
8
0
0
0
0
0
% L
% Met:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
8
8
0
0
0
0
22
0
0
0
0
8
0
0
% N
% Pro:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
8
0
0
0
0
0
0
8
0
0
0
0
0
% Q
% Arg:
0
29
0
0
0
0
0
0
0
50
0
0
8
0
79
% R
% Ser:
0
0
8
0
0
8
8
43
0
0
8
0
0
0
0
% S
% Thr:
0
0
0
36
0
8
0
0
0
0
0
79
8
0
0
% T
% Val:
0
15
0
0
0
22
8
0
15
0
0
8
0
0
0
% V
% Trp:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _