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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TKT All Species: 0
Human Site: S104 Identified Species: 0
UniProt: P29401 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P29401 NP_001055.1 623 67878 S104 L L N L R K I S S D L D G H P
Chimpanzee Pan troglodytes Q5R1W6 623 67821
Rhesus Macaque Macaca mulatta XP_001095403 703 76522
Dog Lupus familis XP_533792 619 67627
Cat Felis silvestris
Mouse Mus musculus P40142 623 67612
Rat Rattus norvegicus P50137 623 67625
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508404 725 77819
Chicken Gallus gallus XP_414333 627 68436
Frog Xenopus laevis NP_001083312 627 67992
Zebra Danio Brachydanio rerio XP_685690 628 69366
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623357 627 67899
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001177524 625 66606
Poplar Tree Populus trichocarpa
Maize Zea mays Q7SIC9 675 72975
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P23254 680 73787
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 61.1 87.3 N.A. 94.6 94 N.A. 74.6 84.2 78.3 71 N.A. N.A. 62.2 N.A. 61.1
Protein Similarity: 100 99.6 72.2 91.8 N.A. 97.9 97.7 N.A. 81.2 92.3 90.4 84.5 N.A. N.A. 76.2 N.A. 76.3
P-Site Identity: 100 0 0 0 N.A. 0 0 N.A. 0 0 0 0 N.A. N.A. 0 N.A. 0
P-Site Similarity: 100 0 0 0 N.A. 0 0 N.A. 0 0 0 0 N.A. N.A. 0 N.A. 0
Percent
Protein Identity: N.A. 25.3 N.A. N.A. 25.4 N.A.
Protein Similarity: N.A. 42.3 N.A. N.A. 41.1 N.A.
P-Site Identity: N.A. 0 N.A. N.A. 0 N.A.
P-Site Similarity: N.A. 0 N.A. N.A. 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 100 0 100 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 % H
% Ile: 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 % K
% Leu: 100 100 0 100 0 0 0 0 0 0 100 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 100 100 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _