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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ERCC5 All Species: 13.03
Human Site: T468 Identified Species: 23.89
UniProt: P28715 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P28715 NP_000114.2 1186 133108 T468 T N E G R E P T D S V P K E Q
Chimpanzee Pan troglodytes XP_509723 1754 197217 T1036 T N E G R E P T D S V P K E Q
Rhesus Macaque Macaca mulatta XP_001096257 1730 194783 T1016 T N E G R E P T D S V P K E Q
Dog Lupus familis XP_542659 1194 133696 C469 H L S H P V F C P G S V L K E
Cat Felis silvestris
Mouse Mus musculus P35689 1170 130839 H468 N E Q T D S A H S F T T A S H
Rat Rattus norvegicus NP_001100380 862 96082 L175 R M D Q K Q A L Q E E F F H N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513433 1466 166007 T734 K D G K E Q T T R S V G T V V
Chicken Gallus gallus NP_001029995 1118 126986 E424 R T D R V Q T E R S K A K E F
Frog Xenopus laevis P14629 1196 134188 N495 D H N L Q G D N C N V P N A K
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001027230 1236 138998 S472 I E E S K Q L S Q A I E E S K
Honey Bee Apis mellifera XP_393585 1047 119475 N360 D I N E Y E L N D D W D S D I
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_791943 1102 123652 D415 K K F F D Q L D A K I S P S Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9ATY5 1479 165649 L460 T R D I Q R N L H L M K E K E
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 67 64.7 74.5 N.A. 65.7 50 N.A. 49.7 54.7 50.3 N.A. N.A. 29.2 29.4 N.A. 22.9
Protein Similarity: 100 67.3 66.3 84.2 N.A. 77.2 57.7 N.A. 62 69.6 64.3 N.A. N.A. 50.8 48.8 N.A. 41.3
P-Site Identity: 100 100 100 0 N.A. 0 0 N.A. 20 20 13.3 N.A. N.A. 6.6 13.3 N.A. 6.6
P-Site Similarity: 100 100 100 13.3 N.A. 6.6 20 N.A. 33.3 33.3 40 N.A. N.A. 53.3 20 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. 25.6 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 43.2 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 46.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 16 0 8 8 0 8 8 8 0 % A
% Cys: 0 0 0 0 0 0 0 8 8 0 0 0 0 0 0 % C
% Asp: 16 8 24 0 16 0 8 8 31 8 0 8 0 8 0 % D
% Glu: 0 16 31 8 8 31 0 8 0 8 8 8 16 31 16 % E
% Phe: 0 0 8 8 0 0 8 0 0 8 0 8 8 0 8 % F
% Gly: 0 0 8 24 0 8 0 0 0 8 0 8 0 0 0 % G
% His: 8 8 0 8 0 0 0 8 8 0 0 0 0 8 8 % H
% Ile: 8 8 0 8 0 0 0 0 0 0 16 0 0 0 8 % I
% Lys: 16 8 0 8 16 0 0 0 0 8 8 8 31 16 16 % K
% Leu: 0 8 0 8 0 0 24 16 0 8 0 0 8 0 0 % L
% Met: 0 8 0 0 0 0 0 0 0 0 8 0 0 0 0 % M
% Asn: 8 24 16 0 0 0 8 16 0 8 0 0 8 0 8 % N
% Pro: 0 0 0 0 8 0 24 0 8 0 0 31 8 0 0 % P
% Gln: 0 0 8 8 16 39 0 0 16 0 0 0 0 0 31 % Q
% Arg: 16 8 0 8 24 8 0 0 16 0 0 0 0 0 0 % R
% Ser: 0 0 8 8 0 8 0 8 8 39 8 8 8 24 0 % S
% Thr: 31 8 0 8 0 0 16 31 0 0 8 8 8 0 0 % T
% Val: 0 0 0 0 8 8 0 0 0 0 39 8 0 8 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % W
% Tyr: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _