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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ERCC5 All Species: 9.39
Human Site: S705 Identified Species: 17.22
UniProt: P28715 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P28715 NP_000114.2 1186 133108 S705 E S L L R D N S E R D D V D G
Chimpanzee Pan troglodytes XP_509723 1754 197217 S1273 E S L L R D N S E R D D V D G
Rhesus Macaque Macaca mulatta XP_001096257 1730 194783 P1253 E S L L R D N P E R E D V V G
Dog Lupus familis XP_542659 1194 133696 G706 G L L K Q N S G S E A L D S E
Cat Felis silvestris
Mouse Mus musculus P35689 1170 130839 S705 E C L L Q D S S D I E A M E G
Rat Rattus norvegicus NP_001100380 862 96082 V412 A S S D N L A V E M L L G N G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513433 1466 166007 A971 K L I A L E E A A D V E R K G
Chicken Gallus gallus NP_001029995 1118 126986 V661 L L N E S D E V Q L A D S Q N
Frog Xenopus laevis P14629 1196 134188 D732 E G N S G S Q D I P L E H D S
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001027230 1236 138998 R709 S D D N K N N R L S P N K T P
Honey Bee Apis mellifera XP_393585 1047 119475 N597 L D K E T S K N K I T F E K E
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_791943 1102 123652 D652 R A T T Q R Q D I L K E L Q K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9ATY5 1479 165649 T697 E R F L D E I T I L K T S G A
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 67 64.7 74.5 N.A. 65.7 50 N.A. 49.7 54.7 50.3 N.A. N.A. 29.2 29.4 N.A. 22.9
Protein Similarity: 100 67.3 66.3 84.2 N.A. 77.2 57.7 N.A. 62 69.6 64.3 N.A. N.A. 50.8 48.8 N.A. 41.3
P-Site Identity: 100 100 80 6.6 N.A. 40 20 N.A. 6.6 13.3 13.3 N.A. N.A. 6.6 0 N.A. 0
P-Site Similarity: 100 100 86.6 26.6 N.A. 80 26.6 N.A. 40 20 20 N.A. N.A. 26.6 13.3 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. 25.6 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 43.2 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 0 8 0 0 8 8 8 0 16 8 0 0 8 % A
% Cys: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 16 8 8 8 39 0 16 8 8 16 31 8 24 0 % D
% Glu: 47 0 0 16 0 16 16 0 31 8 16 24 8 8 16 % E
% Phe: 0 0 8 0 0 0 0 0 0 0 0 8 0 0 0 % F
% Gly: 8 8 0 0 8 0 0 8 0 0 0 0 8 8 47 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % H
% Ile: 0 0 8 0 0 0 8 0 24 16 0 0 0 0 0 % I
% Lys: 8 0 8 8 8 0 8 0 8 0 16 0 8 16 8 % K
% Leu: 16 24 39 39 8 8 0 0 8 24 16 16 8 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 8 0 0 8 0 0 % M
% Asn: 0 0 16 8 8 16 31 8 0 0 0 8 0 8 8 % N
% Pro: 0 0 0 0 0 0 0 8 0 8 8 0 0 0 8 % P
% Gln: 0 0 0 0 24 0 16 0 8 0 0 0 0 16 0 % Q
% Arg: 8 8 0 0 24 8 0 8 0 24 0 0 8 0 0 % R
% Ser: 8 31 8 8 8 16 16 24 8 8 0 0 16 8 8 % S
% Thr: 0 0 8 8 8 0 0 8 0 0 8 8 0 8 0 % T
% Val: 0 0 0 0 0 0 0 16 0 0 8 0 24 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _