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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLD1 All Species: 29.09
Human Site: S575 Identified Species: 53.33
UniProt: P28340 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P28340 NP_002682.2 1107 123631 S575 L L M P V V K S E G G E D Y T
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001116065 1327 147636 S575 L L M P V V R S E G G E D Y T
Dog Lupus familis XP_851285 1107 123714 T575 L L M P V V K T E G G E D Y T
Cat Felis silvestris
Mouse Mus musculus P52431 1105 123765 T573 L L M P V V K T E G G E D Y T
Rat Rattus norvegicus O54747 1103 123583 T571 L L M P V V K T E G G E D Y T
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis NP_001087694 1109 125430 S580 L V M P V V R S E G G E D Y T
Zebra Danio Brachydanio rerio NP_001034899 1105 124931 T579 L V M P V V K T E G G E D Y T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P54358 1092 124887 Q560 I M P S Y T S Q G S D E Q Y E
Honey Bee Apis mellifera XP_623795 1105 126747 Q577 L M P V H R V Q A S D E Q F E
Nematode Worm Caenorhab. elegans P90829 1081 120811 S547 L P V I E A N S G D G E G Y E
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002307042 1081 121993 G557 I P N V K Q A G S E Q G K Y E
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LVN7 1081 121718 G571 L P N A K Q S G S E Q G T Y E
Baker's Yeast Sacchar. cerevisiae P15436 1097 124572 Q581 V I P N M Q S Q A S D D Q Y E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 80.6 94.1 N.A. 89.4 89.8 N.A. N.A. N.A. 70.9 69.7 N.A. 59.4 58.9 49.6 N.A.
Protein Similarity: 100 N.A. 81.5 96.4 N.A. 94.1 94.3 N.A. N.A. N.A. 84 83 N.A. 74.8 74.4 67.9 N.A.
P-Site Identity: 100 N.A. 93.3 93.3 N.A. 93.3 93.3 N.A. N.A. N.A. 86.6 86.6 N.A. 13.3 13.3 33.3 N.A.
P-Site Similarity: 100 N.A. 100 100 N.A. 100 100 N.A. N.A. N.A. 100 100 N.A. 26.6 26.6 40 N.A.
Percent
Protein Identity: 54.9 N.A. N.A. 50.8 47 N.A.
Protein Similarity: 71 N.A. N.A. 67.4 65.1 N.A.
P-Site Identity: 6.6 N.A. N.A. 13.3 6.6 N.A.
P-Site Similarity: 13.3 N.A. N.A. 13.3 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 0 8 8 0 16 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 8 24 8 54 0 0 % D
% Glu: 0 0 0 0 8 0 0 0 54 16 0 77 0 0 47 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % F
% Gly: 0 0 0 0 0 0 0 16 16 54 62 16 8 0 0 % G
% His: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 16 8 0 8 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 16 0 39 0 0 0 0 0 8 0 0 % K
% Leu: 77 39 0 0 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 16 54 0 8 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 16 8 0 0 8 0 0 0 0 0 0 0 0 % N
% Pro: 0 24 24 54 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 24 0 24 0 0 16 0 24 0 0 % Q
% Arg: 0 0 0 0 0 8 16 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 8 0 0 24 31 16 24 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 8 0 31 0 0 0 0 8 0 54 % T
% Val: 8 16 8 16 54 54 8 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 8 0 0 0 0 0 0 0 0 93 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _