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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ITPKB All Species: 12.73
Human Site: S412 Identified Species: 25.45
UniProt: P27987 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P27987 NP_002212.3 946 102376 S412 S S D S L S W S R L P R A L A
Chimpanzee Pan troglodytes XP_001141610 946 102163 S412 S S D A L S W S R L P R A L A
Rhesus Macaque Macaca mulatta XP_001089824 939 101522 S407 S S D A L S W S R L P R A L A
Dog Lupus familis XP_547504 936 98978 P411 E S R V R P L P D P G S S G G
Cat Felis silvestris
Mouse Mus musculus Q7TS72 678 74474 W180 E L D R S D M W Q T L P E R D
Rat Rattus norvegicus P42335 934 101801 S403 L S E N P R W S R L P G D P G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513057 370 41159
Chicken Gallus gallus XP_415039 637 69972 S139 S P W S P P P S S P R P S S P
Frog Xenopus laevis NP_001088157 516 58252 G18 T A G S D C L G K V A H R D D
Zebra Danio Brachydanio rerio XP_691475 657 73298 P159 P R I S R K S P H Y F A P V Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_572875 669 73198 P171 A S N A N A L P S S S S K K I
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_795627 356 40840
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.5 93.6 73.7 N.A. 34.4 76.2 N.A. 31.7 51.1 32.6 44.9 N.A. 32.6 N.A. N.A. 25.2
Protein Similarity: 100 99 95.1 79.1 N.A. 46.7 80.9 N.A. 34.1 57 41.6 54.1 N.A. 46.2 N.A. N.A. 30
P-Site Identity: 100 93.3 93.3 6.6 N.A. 6.6 40 N.A. 0 20 6.6 6.6 N.A. 6.6 N.A. N.A. 0
P-Site Similarity: 100 100 100 13.3 N.A. 13.3 53.3 N.A. 0 26.6 33.3 13.3 N.A. 33.3 N.A. N.A. 0
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 9 0 25 0 9 0 0 0 0 9 9 25 0 25 % A
% Cys: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 34 0 9 9 0 0 9 0 0 0 9 9 17 % D
% Glu: 17 0 9 0 0 0 0 0 0 0 0 0 9 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % F
% Gly: 0 0 9 0 0 0 0 9 0 0 9 9 0 9 17 % G
% His: 0 0 0 0 0 0 0 0 9 0 0 9 0 0 0 % H
% Ile: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 9 % I
% Lys: 0 0 0 0 0 9 0 0 9 0 0 0 9 9 0 % K
% Leu: 9 9 0 0 25 0 25 0 0 34 9 0 0 25 0 % L
% Met: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 9 9 9 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 9 9 0 0 17 17 9 25 0 17 34 17 9 9 9 % P
% Gln: 0 0 0 0 0 0 0 0 9 0 0 0 0 0 9 % Q
% Arg: 0 9 9 9 17 9 0 0 34 0 9 25 9 9 0 % R
% Ser: 34 50 0 34 9 25 9 42 17 9 9 17 17 9 0 % S
% Thr: 9 0 0 0 0 0 0 0 0 9 0 0 0 0 0 % T
% Val: 0 0 0 9 0 0 0 0 0 9 0 0 0 9 0 % V
% Trp: 0 0 9 0 0 0 34 9 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 9 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _