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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MARK3 All Species: 28.79
Human Site: S522 Identified Species: 57.58
UniProt: P27448 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P27448 NP_001122390.1 776 87005 S522 V P S S N T A S G G M T R R N
Chimpanzee Pan troglodytes XP_510184 737 82858 S483 V P S S N T A S G G M I R R N
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_868647 777 86967 S523 V P S T N T A S G G M T R R N
Cat Felis silvestris
Mouse Mus musculus Q03141 753 84371 S499 V P S S N T A S G G M T R R N
Rat Rattus norvegicus Q8VHF0 797 88733 S499 V P S S N A A S G G M T R R N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508081 736 82480 S491 V P S N N T T S G G M T R R N
Chicken Gallus gallus Q9IA88 798 88848 P533 G Q V M T G S P A T A R M T S
Frog Xenopus laevis NP_001084256 725 81522 S495 V P T T N S T S S G M T R R N
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 G734 A G L M Q T H G G P S A V Q Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9TW45 1192 126331 T938 P P H Q H Q L T H N A S F S V
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q38997 535 61163 P307 R Y L A V P P P D T V Q Q A K
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 S403 M K A N K S V S D E L D T F L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.7 N.A. 96.4 N.A. 94 89.9 N.A. 90.5 31.4 85.6 26.5 N.A. N.A. N.A. 39.8 N.A.
Protein Similarity: 100 94.7 N.A. 97.4 N.A. 95 91.2 N.A. 92.9 50.7 89.5 42.6 N.A. N.A. N.A. 51 N.A.
P-Site Identity: 100 93.3 N.A. 93.3 N.A. 100 93.3 N.A. 86.6 0 66.6 13.3 N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: 100 93.3 N.A. 100 N.A. 100 93.3 N.A. 93.3 13.3 86.6 20 N.A. N.A. N.A. 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 27 27.3 N.A.
Protein Similarity: N.A. N.A. N.A. 44 45.8 N.A.
P-Site Identity: N.A. N.A. N.A. 0 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 0 9 9 0 9 42 0 9 0 17 9 0 9 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 17 0 0 9 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 9 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 9 9 0 % F
% Gly: 9 9 0 0 0 9 0 9 59 59 0 0 0 0 0 % G
% His: 0 0 9 0 9 0 9 0 9 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % I
% Lys: 0 9 0 0 9 0 0 0 0 0 0 0 0 0 9 % K
% Leu: 0 0 17 0 0 0 9 0 0 0 9 0 0 0 9 % L
% Met: 9 0 0 17 0 0 0 0 0 0 59 0 9 0 0 % M
% Asn: 0 0 0 17 59 0 0 0 0 9 0 0 0 0 59 % N
% Pro: 9 67 0 0 0 9 9 17 0 9 0 0 0 0 0 % P
% Gln: 0 9 0 9 9 9 0 0 0 0 0 9 9 9 0 % Q
% Arg: 9 0 0 0 0 0 0 0 0 0 0 9 59 59 0 % R
% Ser: 0 0 50 34 0 17 9 67 9 0 9 9 0 9 9 % S
% Thr: 0 0 9 17 9 50 17 9 0 17 0 50 9 9 0 % T
% Val: 59 0 9 0 9 0 9 0 0 0 9 0 9 0 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 9 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _