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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ACVR2A
All Species:
21.82
Human Site:
Y444
Identified Species:
40
UniProt:
P27037
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P27037
NP_001607.1
513
57848
Y444
K
R
P
V
L
R
D
Y
W
Q
K
H
A
G
M
Chimpanzee
Pan troglodytes
XP_001171684
516
58074
H447
M
R
P
T
I
K
D
H
W
L
K
H
P
G
L
Rhesus Macaque
Macaca mulatta
XP_001095641
521
58808
Y452
K
R
P
V
L
R
D
Y
W
Q
K
H
A
G
M
Dog
Lupus familis
XP_857260
513
57943
Y444
K
R
P
V
L
R
D
Y
W
Q
K
H
A
G
M
Cat
Felis silvestris
Mouse
Mus musculus
P27038
513
57871
Y444
K
R
P
V
L
R
D
Y
W
Q
K
H
A
G
M
Rat
Rattus norvegicus
P38444
513
57874
Y444
K
R
P
V
L
R
D
Y
W
Q
K
H
A
G
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518896
634
71047
N566
E
H
R
G
G
K
E
N
N
D
V
G
R
G
R
Chicken
Gallus gallus
Q90669
513
58073
C444
K
R
P
V
L
R
E
C
W
Q
K
H
S
G
M
Frog
Xenopus laevis
P27039
514
57885
C445
K
R
P
I
L
R
E
C
W
Q
K
H
A
G
M
Zebra Danio
Brachydanio rerio
NP_001103748
514
57908
C445
L
R
P
T
L
R
E
C
W
Q
K
H
P
G
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395928
531
60411
T459
E
R
P
I
I
L
E
T
W
R
K
H
P
G
L
Nematode Worm
Caenorhab. elegans
P50488
744
84391
E562
E
R
P
Q
W
R
D
E
I
I
K
H
E
Y
M
Sea Urchin
Strong. purpuratus
XP_780388
541
60817
H445
K
R
P
V
I
S
D
H
W
L
K
H
R
G
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67
98.4
98.8
N.A.
99.6
99
N.A.
53.7
92.5
87.9
78.7
N.A.
N.A.
53.4
25.2
51.3
Protein Similarity:
100
83.5
98.4
100
N.A.
100
99.6
N.A.
60.7
97.8
94.9
89.3
N.A.
N.A.
69.6
40.4
64.7
P-Site Identity:
100
46.6
100
100
N.A.
100
100
N.A.
6.6
80
80
60
N.A.
N.A.
40
46.6
60
P-Site Similarity:
100
73.3
100
100
N.A.
100
100
N.A.
26.6
93.3
93.3
73.3
N.A.
N.A.
80
53.3
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
47
0
0
% A
% Cys:
0
0
0
0
0
0
0
24
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
62
0
0
8
0
0
0
0
0
% D
% Glu:
24
0
0
0
0
0
39
8
0
0
0
0
8
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
8
8
0
0
0
0
0
0
8
0
93
0
% G
% His:
0
8
0
0
0
0
0
16
0
0
0
93
0
0
0
% H
% Ile:
0
0
0
16
24
0
0
0
8
8
0
0
0
0
0
% I
% Lys:
62
0
0
0
0
16
0
0
0
0
93
0
0
0
0
% K
% Leu:
8
0
0
0
62
8
0
0
0
16
0
0
0
0
31
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
62
% M
% Asn:
0
0
0
0
0
0
0
8
8
0
0
0
0
0
0
% N
% Pro:
0
0
93
0
0
0
0
0
0
0
0
0
24
0
0
% P
% Gln:
0
0
0
8
0
0
0
0
0
62
0
0
0
0
0
% Q
% Arg:
0
93
8
0
0
70
0
0
0
8
0
0
16
0
8
% R
% Ser:
0
0
0
0
0
8
0
0
0
0
0
0
8
0
0
% S
% Thr:
0
0
0
16
0
0
0
8
0
0
0
0
0
0
0
% T
% Val:
0
0
0
54
0
0
0
0
0
0
8
0
0
0
0
% V
% Trp:
0
0
0
0
8
0
0
0
85
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
39
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _