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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ACVR2A
All Species:
47.58
Human Site:
S274
Identified Species:
87.22
UniProt:
P27037
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P27037
NP_001607.1
513
57848
S274
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
Chimpanzee
Pan troglodytes
XP_001171684
516
58074
S276
T
A
F
H
D
K
G
S
L
T
D
Y
L
K
G
Rhesus Macaque
Macaca mulatta
XP_001095641
521
58808
S282
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
Dog
Lupus familis
XP_857260
513
57943
S274
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
Cat
Felis silvestris
Mouse
Mus musculus
P27038
513
57871
S274
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
Rat
Rattus norvegicus
P38444
513
57874
S274
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518896
634
71047
T408
I
G
A
E
K
R
G
T
S
I
D
V
D
L
W
Chicken
Gallus gallus
Q90669
513
58073
S274
T
A
F
H
E
K
G
S
L
T
D
F
L
K
A
Frog
Xenopus laevis
P27039
514
57885
S275
T
A
F
H
E
K
G
S
L
T
D
Y
L
K
A
Zebra Danio
Brachydanio rerio
NP_001103748
514
57908
S275
T
A
Y
H
E
K
S
S
L
T
G
Y
L
K
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395928
531
60411
S288
T
S
Y
H
E
K
G
S
L
C
D
Y
L
K
A
Nematode Worm
Caenorhab. elegans
P50488
744
84391
S392
T
E
F
H
E
R
L
S
L
Y
E
L
L
K
N
Sea Urchin
Strong. purpuratus
XP_780388
541
60817
S273
S
E
F
H
H
H
G
S
L
C
D
Y
L
K
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67
98.4
98.8
N.A.
99.6
99
N.A.
53.7
92.5
87.9
78.7
N.A.
N.A.
53.4
25.2
51.3
Protein Similarity:
100
83.5
98.4
100
N.A.
100
99.6
N.A.
60.7
97.8
94.9
89.3
N.A.
N.A.
69.6
40.4
64.7
P-Site Identity:
100
73.3
100
100
N.A.
100
100
N.A.
13.3
93.3
86.6
66.6
N.A.
N.A.
73.3
53.3
60
P-Site Similarity:
100
93.3
100
100
N.A.
100
100
N.A.
33.3
100
100
86.6
N.A.
N.A.
93.3
66.6
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
70
8
0
0
0
0
0
0
0
0
0
0
0
77
% A
% Cys:
0
0
0
0
0
0
0
0
0
16
0
0
0
0
0
% C
% Asp:
0
0
0
0
8
0
0
0
0
0
85
0
8
0
0
% D
% Glu:
0
16
0
8
77
0
0
0
0
0
8
0
0
0
0
% E
% Phe:
0
0
77
0
0
0
0
0
0
0
0
47
0
0
0
% F
% Gly:
0
8
0
0
0
0
85
0
0
0
8
0
0
0
8
% G
% His:
0
0
0
93
8
8
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% I
% Lys:
0
0
0
0
8
77
0
0
0
0
0
0
0
93
0
% K
% Leu:
0
0
0
0
0
0
8
0
93
0
0
8
93
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
16
0
0
0
0
0
0
0
0
0
% R
% Ser:
8
8
0
0
0
0
8
93
8
39
0
0
0
0
0
% S
% Thr:
85
0
0
0
0
0
0
8
0
31
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
0
0
16
0
0
0
0
0
0
8
0
39
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _