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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
U2AF2
All Species:
34.85
Human Site:
Y395
Identified Species:
69.7
UniProt:
P26368
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P26368
NP_001012496.1
475
53501
Y395
E
L
L
D
D
E
E
Y
E
E
I
V
E
D
V
Chimpanzee
Pan troglodytes
XP_530073
713
78555
Y633
E
L
L
D
D
E
E
Y
E
E
I
V
E
D
V
Rhesus Macaque
Macaca mulatta
XP_001091568
467
51268
Y387
E
L
L
D
D
E
E
Y
E
E
I
V
E
D
V
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P26369
475
53499
Y395
E
L
L
D
D
E
E
Y
E
E
I
V
E
D
V
Rat
Rattus norvegicus
Q63285
419
46487
K348
E
D
V
V
E
D
V
K
E
E
C
Q
K
Y
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001080595
456
51328
Y376
E
L
I
D
D
D
E
Y
E
E
I
V
E
D
V
Zebra Danio
Brachydanio rerio
NP_991252
475
53612
Y395
E
L
I
D
D
E
E
Y
E
E
I
V
E
D
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24562
416
46636
K345
E
D
I
L
E
D
I
K
E
E
C
T
K
Y
G
Honey Bee
Apis mellifera
XP_623055
432
48801
K361
E
D
I
L
E
D
I
K
E
E
C
N
K
Y
G
Nematode Worm
Caenorhab. elegans
P90978
496
55412
Y417
E
L
K
A
D
D
E
Y
E
E
I
L
E
D
V
Sea Urchin
Strong. purpuratus
XP_001189425
444
50005
Y365
E
L
K
D
D
E
E
Y
D
D
I
V
E
D
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8L716
589
66297
Y507
D
L
R
D
D
E
E
Y
A
E
I
M
E
D
M
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
53.4
87.5
N.A.
N.A.
99.7
20
N.A.
N.A.
N.A.
92
86.3
N.A.
66.7
66.7
51.4
62.9
Protein Similarity:
100
57.2
89.2
N.A.
N.A.
99.7
37.6
N.A.
N.A.
N.A.
94.7
92.2
N.A.
77
77.8
62.5
75.5
P-Site Identity:
100
100
100
N.A.
N.A.
100
20
N.A.
N.A.
N.A.
86.6
93.3
N.A.
20
20
73.3
80
P-Site Similarity:
100
100
100
N.A.
N.A.
100
46.6
N.A.
N.A.
N.A.
100
100
N.A.
46.6
46.6
86.6
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
37.6
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
50.7
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
66.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
86.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
9
0
0
0
0
9
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
25
0
0
0
0
% C
% Asp:
9
25
0
67
75
42
0
0
9
9
0
0
0
75
0
% D
% Glu:
92
0
0
0
25
59
75
0
84
92
0
0
75
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
25
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
34
0
0
0
17
0
0
0
75
0
0
0
0
% I
% Lys:
0
0
17
0
0
0
0
25
0
0
0
0
25
0
0
% K
% Leu:
0
75
34
17
0
0
0
0
0
0
0
9
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
9
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% Q
% Arg:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% T
% Val:
0
0
9
9
0
0
9
0
0
0
0
59
0
0
67
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
75
0
0
0
0
0
25
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _