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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM3
All Species:
47.27
Human Site:
T614
Identified Species:
74.29
UniProt:
P25205
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P25205
NP_002379.2
808
90981
T614
T
A
R
T
S
P
V
T
A
R
T
L
E
T
L
Chimpanzee
Pan troglodytes
XP_001151750
808
90957
T614
T
A
R
T
S
P
V
T
A
R
T
L
E
T
L
Rhesus Macaque
Macaca mulatta
XP_001106966
808
90990
T614
T
A
R
T
S
P
V
T
A
R
T
L
E
T
L
Dog
Lupus familis
XP_538960
916
102667
T722
T
A
R
T
S
P
V
T
A
R
T
L
E
T
L
Cat
Felis silvestris
Mouse
Mus musculus
P25206
812
91528
T614
T
A
R
T
S
P
V
T
A
R
T
L
E
T
L
Rat
Rattus norvegicus
XP_001070728
813
91641
T614
T
A
R
T
S
P
V
T
A
R
T
L
E
T
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZMN2
812
91233
T615
I
A
R
T
S
P
V
T
A
R
T
L
E
T
L
Frog
Xenopus laevis
Q7ZXZ0
806
90528
T614
V
A
R
T
S
P
V
T
A
R
S
L
E
T
L
Zebra Danio
Brachydanio rerio
NP_997732
807
90502
T613
I
A
R
T
S
P
V
T
A
R
T
L
E
T
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_511048
819
90900
T608
V
A
R
T
Q
P
I
T
A
R
T
L
E
T
L
Honey Bee
Apis mellifera
XP_625020
811
91329
T612
T
A
R
T
Q
P
V
T
A
R
T
L
E
T
L
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
D571
V
M
T
M
F
D
T
D
G
F
L
T
I
E
F
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q43704
768
85163
A577
Q
P
R
L
T
D
E
A
S
D
H
I
A
T
S
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FL33
776
86338
K587
R
N
A
G
S
D
T
K
T
G
G
T
L
P
I
Baker's Yeast
Sacchar. cerevisiae
P24279
971
107499
T698
N
T
K
K
S
P
I
T
A
R
T
L
E
T
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.5
86
N.A.
92.9
93.3
N.A.
N.A.
81.4
80.1
75.9
N.A.
62.5
62.7
30.8
N.A.
Protein Similarity:
100
99.8
100
87.2
N.A.
96.6
97
N.A.
N.A.
92
90.7
88.1
N.A.
80
78.6
49.5
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
93.3
86.6
93.3
N.A.
80
93.3
0
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
93.3
93.3
93.3
N.A.
86.6
93.3
0
N.A.
Percent
Protein Identity:
N.A.
47.6
N.A.
49.3
39.8
N.A.
Protein Similarity:
N.A.
66
N.A.
68.1
54.7
N.A.
P-Site Identity:
N.A.
13.3
N.A.
6.6
66.6
N.A.
P-Site Similarity:
N.A.
33.3
N.A.
13.3
80
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
74
7
0
0
0
0
7
80
0
0
0
7
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
20
0
7
0
7
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
7
0
0
0
0
0
80
7
0
% E
% Phe:
0
0
0
0
7
0
0
0
0
7
0
0
0
0
7
% F
% Gly:
0
0
0
7
0
0
0
0
7
7
7
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% H
% Ile:
14
0
0
0
0
0
14
0
0
0
0
7
7
0
7
% I
% Lys:
0
0
7
7
0
0
0
7
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
7
0
0
0
0
0
0
7
80
7
0
80
% L
% Met:
0
7
0
7
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
7
0
0
0
80
0
0
0
0
0
0
0
7
0
% P
% Gln:
7
0
0
0
14
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
7
0
80
0
0
0
0
0
0
80
0
0
0
0
0
% R
% Ser:
0
0
0
0
74
0
0
0
7
0
7
0
0
0
7
% S
% Thr:
47
7
7
74
7
0
14
80
7
0
74
14
0
87
0
% T
% Val:
20
0
0
0
0
0
67
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _