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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MCM3 All Species: 37.58
Human Site: T290 Identified Species: 59.05
UniProt: P25205 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P25205 NP_002379.2 808 90981 T290 K I K K F S K T R S K D I F D
Chimpanzee Pan troglodytes XP_001151750 808 90957 T290 K I K K F S K T R S K D I F D
Rhesus Macaque Macaca mulatta XP_001106966 808 90990 T290 K I K K F S K T R S K D I F D
Dog Lupus familis XP_538960 916 102667 T398 K I K K F S K T R S K D I F D
Cat Felis silvestris
Mouse Mus musculus P25206 812 91528 T290 K I K K F S K T R S K D V F E
Rat Rattus norvegicus XP_001070728 813 91641 T290 K I K K F S K T R S K D V F E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q5ZMN2 812 91233 S291 K I K R F S K S R S K D I F N
Frog Xenopus laevis Q7ZXZ0 806 90528 S290 K I K K F S K S H S K D V F E
Zebra Danio Brachydanio rerio NP_997732 807 90502 S289 K I K S F C R S R S K N V F D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_511048 819 90900 N287 L C K K L A K N N D I F E L L
Honey Bee Apis mellifera XP_625020 811 91329 N286 M C K K L A K N N P C K N I F
Nematode Worm Caenorhab. elegans Q21902 759 84917 G268 G N R V T I V G V Y S I K K L
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays Q43704 768 85163 E276 N A P V Y T R E D L K R M K E
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FL33 776 86338 R281 D N I K N I A R R D D A F D L
Baker's Yeast Sacchar. cerevisiae P24279 971 107499 S354 I R N I N K L S K K K D I F D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 99.5 86 N.A. 92.9 93.3 N.A. N.A. 81.4 80.1 75.9 N.A. 62.5 62.7 30.8 N.A.
Protein Similarity: 100 99.8 100 87.2 N.A. 96.6 97 N.A. N.A. 92 90.7 88.1 N.A. 80 78.6 49.5 N.A.
P-Site Identity: 100 100 100 100 N.A. 86.6 86.6 N.A. N.A. 80 73.3 60 N.A. 20 20 0 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. N.A. 100 93.3 86.6 N.A. 26.6 26.6 6.6 N.A.
Percent
Protein Identity: N.A. 47.6 N.A. 49.3 39.8 N.A.
Protein Similarity: N.A. 66 N.A. 68.1 54.7 N.A.
P-Site Identity: N.A. 6.6 N.A. 13.3 33.3 N.A.
P-Site Similarity: N.A. 40 N.A. 13.3 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 0 0 0 14 7 0 0 0 0 7 0 0 0 % A
% Cys: 0 14 0 0 0 7 0 0 0 0 7 0 0 0 0 % C
% Asp: 7 0 0 0 0 0 0 0 7 14 7 60 0 7 40 % D
% Glu: 0 0 0 0 0 0 0 7 0 0 0 0 7 0 27 % E
% Phe: 0 0 0 0 60 0 0 0 0 0 0 7 7 67 7 % F
% Gly: 7 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % H
% Ile: 7 60 7 7 0 14 0 0 0 0 7 7 40 7 0 % I
% Lys: 60 0 74 67 0 7 67 0 7 7 74 7 7 14 0 % K
% Leu: 7 0 0 0 14 0 7 0 0 7 0 0 0 7 20 % L
% Met: 7 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % M
% Asn: 7 14 7 0 14 0 0 14 14 0 0 7 7 0 7 % N
% Pro: 0 0 7 0 0 0 0 0 0 7 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 7 7 7 0 0 14 7 60 0 0 7 0 0 0 % R
% Ser: 0 0 0 7 0 54 0 27 0 60 7 0 0 0 0 % S
% Thr: 0 0 0 0 7 7 0 40 0 0 0 0 0 0 0 % T
% Val: 0 0 0 14 0 0 7 0 7 0 0 0 27 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 7 0 0 0 0 7 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _