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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY2C
All Species:
33.94
Human Site:
S658
Identified Species:
62.22
UniProt:
P25092
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P25092
NP_004954.2
1073
123369
S658
H
L
R
Q
A
N
I
S
Q
K
G
D
V
Y
S
Chimpanzee
Pan troglodytes
XP_528746
1073
123536
S658
H
L
R
Q
A
N
I
S
Q
K
G
D
V
Y
S
Rhesus Macaque
Macaca mulatta
XP_001089601
1073
123492
S658
H
L
R
Q
A
N
V
S
Q
K
G
D
V
Y
S
Dog
Lupus familis
XP_543798
1072
122882
S656
H
L
R
Q
A
N
I
S
Q
K
G
D
V
Y
S
Cat
Felis silvestris
Mouse
Mus musculus
Q3UWA6
1072
123214
S658
H
L
R
Q
A
T
I
S
Q
K
G
D
V
Y
S
Rat
Rattus norvegicus
P23897
1072
123448
S657
H
L
R
Q
A
T
I
S
Q
K
G
D
V
Y
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520217
1075
122497
S659
H
L
R
R
A
S
E
S
Q
K
G
D
V
Y
S
Chicken
Gallus gallus
XP_416207
1070
123254
S655
H
L
R
H
A
D
V
S
Q
K
G
D
V
Y
S
Frog
Xenopus laevis
NP_001079334
1065
122503
S650
H
L
H
Q
E
G
F
S
Q
K
G
D
V
Y
S
Zebra Danio
Brachydanio rerio
XP_700803
484
55110
M95
H
T
S
C
C
S
D
M
A
E
K
L
Y
L
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q07553
1163
130896
M696
E
L
K
R
A
L
C
M
A
P
E
L
L
R
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09435
1137
128085
R728
W
V
A
P
E
V
L
R
G
S
L
S
V
S
Q
Sea Urchin
Strong. purpuratus
P16065
1125
126238
K663
I
L
E
N
D
D
I
K
L
D
S
M
F
L
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
97.5
87.7
N.A.
81.8
82.4
N.A.
73.5
67.7
62.4
31.4
N.A.
27.9
N.A.
24.8
28.6
Protein Similarity:
100
99.5
98.7
93.5
N.A.
90.1
90.7
N.A.
83.7
80.6
77
37.3
N.A.
45.2
N.A.
45.2
46.3
P-Site Identity:
100
100
93.3
100
N.A.
93.3
93.3
N.A.
80
80
73.3
6.6
N.A.
13.3
N.A.
6.6
20
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
93.3
93.3
73.3
20
N.A.
33.3
N.A.
20
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
70
0
0
0
16
0
0
0
0
0
0
% A
% Cys:
0
0
0
8
8
0
8
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
8
16
8
0
0
8
0
70
0
0
8
% D
% Glu:
8
0
8
0
16
0
8
0
0
8
8
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
8
0
0
0
0
0
8
0
0
% F
% Gly:
0
0
0
0
0
8
0
0
8
0
70
0
0
0
0
% G
% His:
77
0
8
8
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
0
0
47
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
8
0
0
0
0
8
0
70
8
0
0
0
0
% K
% Leu:
0
85
0
0
0
8
8
0
8
0
8
16
8
16
0
% L
% Met:
0
0
0
0
0
0
0
16
0
0
0
8
0
0
0
% M
% Asn:
0
0
0
8
0
31
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
8
0
0
0
0
0
8
0
0
0
0
0
% P
% Gln:
0
0
0
54
0
0
0
0
70
0
0
0
0
0
8
% Q
% Arg:
0
0
62
16
0
0
0
8
0
0
0
0
0
8
0
% R
% Ser:
0
0
8
0
0
16
0
70
0
8
8
8
0
8
77
% S
% Thr:
0
8
0
0
0
16
0
0
0
0
0
0
0
0
0
% T
% Val:
0
8
0
0
0
8
16
0
0
0
0
0
77
0
8
% V
% Trp:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
8
70
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _