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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDK2 All Species: 36.06
Human Site: T158 Identified Species: 49.58
UniProt: P24941 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P24941 NP_001789.2 298 33930 T158 A F G V P V R T Y T H E V V T
Chimpanzee Pan troglodytes XP_523720 325 36841 T178 A F G V P L R T Y T H E V V T
Rhesus Macaque Macaca mulatta XP_001113345 298 33812 T158 A F G V P V R T Y T H E V V T
Dog Lupus familis XP_856049 298 33839 T158 A F G V P V R T Y T H E V V T
Cat Felis silvestris
Mouse Mus musculus P97377 346 38960 K206 V C T Q H H A K C C G E H R R
Rat Rattus norvegicus Q63699 298 33869 T158 A F G V P V R T Y T H E V V T
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P13863 303 34670 V159 A F G I P V R V Y T H E V V T
Frog Xenopus laevis P23437 297 33852 T158 A F G V P V R T F T H E V V T
Zebra Danio Brachydanio rerio NP_998571 298 34001 T158 A F G V P V R T Y T H E V V T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P23573 314 35870 A161 A F N V P M R A Y T H E V V T
Honey Bee Apis mellifera XP_393450 299 34033 T157 T F G V P V R T Y T H E I V T
Nematode Worm Caenorhab. elegans P34556 332 38277 V177 A I G I P I R V Y T H E V V T
Sea Urchin Strong. purpuratus XP_790847 299 34142 T158 A F G V P V R T Y T H E V V T
Poplar Tree Populus trichocarpa XP_002306004 294 33768 A152 A D F G L A R A F G I P V R T
Maize Zea mays P23111 294 33816 A152 A D F G L A R A F G I P V R T
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P24100 294 34012 A152 A D F G L A R A F G I P V R T
Baker's Yeast Sacchar. cerevisiae P00546 298 34043 R159 L G D F G L A R A F G V P L R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 69.8 99.6 98.9 N.A. 85.2 98.6 N.A. N.A. 65.3 88.9 90.2 N.A. 62.7 69.9 56.9 75.9
Protein Similarity: 100 79.6 99.6 99.6 N.A. 85.8 99.6 N.A. N.A. 77.8 94.9 94.9 N.A. 74.8 82.2 69.8 88.6
P-Site Identity: 100 93.3 100 100 N.A. 6.6 100 N.A. N.A. 86.6 93.3 100 N.A. 80 86.6 73.3 100
P-Site Similarity: 100 100 100 100 N.A. 6.6 100 N.A. N.A. 93.3 100 100 N.A. 86.6 93.3 86.6 100
Percent
Protein Identity: 66.4 66.7 N.A. 67.1 62.4 N.A.
Protein Similarity: 83.2 82.2 N.A. 81.5 79.1 N.A.
P-Site Identity: 26.6 26.6 N.A. 26.6 0 N.A.
P-Site Similarity: 33.3 33.3 N.A. 33.3 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 83 0 0 0 0 18 12 24 6 0 0 0 0 0 0 % A
% Cys: 0 6 0 0 0 0 0 0 6 6 0 0 0 0 0 % C
% Asp: 0 18 6 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 77 0 0 0 % E
% Phe: 0 65 18 6 0 0 0 0 24 6 0 0 0 0 0 % F
% Gly: 0 6 65 18 6 0 0 0 0 18 12 0 0 0 0 % G
% His: 0 0 0 0 6 6 0 0 0 0 71 0 6 0 0 % H
% Ile: 0 6 0 12 0 6 0 0 0 0 18 0 6 0 0 % I
% Lys: 0 0 0 0 0 0 0 6 0 0 0 0 0 0 0 % K
% Leu: 6 0 0 0 18 12 0 0 0 0 0 0 0 6 0 % L
% Met: 0 0 0 0 0 6 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 6 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 71 0 0 0 0 0 0 18 6 0 0 % P
% Gln: 0 0 0 6 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 89 6 0 0 0 0 0 24 12 % R
% Ser: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % S
% Thr: 6 0 6 0 0 0 0 53 0 71 0 0 0 0 89 % T
% Val: 6 0 0 59 0 53 0 12 0 0 0 6 83 71 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 65 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _