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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RRM1
All Species:
50.91
Human Site:
T646
Identified Species:
74.67
UniProt:
P23921
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P23921
NP_001024.1
792
90070
T646
P
H
L
L
K
D
L
T
E
R
G
L
W
H
E
Chimpanzee
Pan troglodytes
XP_001160029
792
90066
T646
P
H
L
L
K
D
L
T
E
R
G
L
W
H
E
Rhesus Macaque
Macaca mulatta
XP_001113010
792
90110
T646
P
H
L
L
K
D
L
T
E
R
G
L
W
H
E
Dog
Lupus familis
XP_534027
792
90191
T646
P
H
L
L
K
D
L
T
E
R
G
L
W
N
E
Cat
Felis silvestris
Mouse
Mus musculus
P07742
792
90201
T646
P
H
L
L
K
D
L
T
E
R
G
L
W
N
K
Rat
Rattus norvegicus
NP_001013254
792
90275
T646
P
H
L
L
K
D
L
T
E
R
G
L
W
N
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505371
792
90170
T646
P
H
L
L
K
D
L
T
E
R
G
L
W
N
E
Chicken
Gallus gallus
NP_001026008
790
90074
T646
P
H
L
L
K
D
L
T
E
R
G
L
W
N
E
Frog
Xenopus laevis
NP_001084312
797
90815
T646
P
H
L
M
K
D
L
T
E
Q
G
L
W
N
E
Zebra Danio
Brachydanio rerio
P79732
794
89798
T646
P
H
L
L
K
D
L
T
E
R
G
L
W
N
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48591
812
91959
T657
H
H
L
L
R
D
L
T
E
L
D
L
W
D
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q03604
788
88951
M647
F
Q
I
V
N
P
H
M
L
K
D
L
V
E
R
Sea Urchin
Strong. purpuratus
XP_780425
797
89848
T648
H
H
L
L
R
D
L
T
D
M
G
L
W
S
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SJ20
816
91797
T665
K
H
L
L
H
D
L
T
D
M
G
L
W
T
P
Baker's Yeast
Sacchar. cerevisiae
P21672
869
97496
V650
P
Y
L
L
R
D
L
V
D
L
G
I
W
D
D
Red Bread Mold
Neurospora crassa
Q9UW15
929
103785
V647
P
W
L
L
R
D
L
V
E
M
G
L
W
S
D
Conservation
Percent
Protein Identity:
100
99.8
99.3
97.9
N.A.
97.3
97.4
N.A.
96.2
94
89
89.1
N.A.
73.7
N.A.
73.6
78.9
Protein Similarity:
100
100
99.6
99.3
N.A.
98.6
98.9
N.A.
98.9
97.7
95.7
94.2
N.A.
84.3
N.A.
85.8
88.8
P-Site Identity:
100
100
100
93.3
N.A.
86.6
93.3
N.A.
93.3
93.3
80
93.3
N.A.
60
N.A.
6.6
60
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
73.3
N.A.
26.6
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
67.8
60.6
62.5
Protein Similarity:
N.A.
N.A.
N.A.
80.3
77.2
73.4
P-Site Identity:
N.A.
N.A.
N.A.
60
46.6
60
P-Site Similarity:
N.A.
N.A.
N.A.
66.6
80
73.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
94
0
0
19
0
13
0
0
13
25
% D
% Glu:
0
0
0
0
0
0
0
0
75
0
0
0
0
7
57
% E
% Phe:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
88
0
0
0
0
% G
% His:
13
82
0
0
7
0
7
0
0
0
0
0
0
19
0
% H
% Ile:
0
0
7
0
0
0
0
0
0
0
0
7
0
0
0
% I
% Lys:
7
0
0
0
63
0
0
0
0
7
0
0
0
0
7
% K
% Leu:
0
0
94
88
0
0
94
0
7
13
0
94
0
0
0
% L
% Met:
0
0
0
7
0
0
0
7
0
19
0
0
0
0
0
% M
% Asn:
0
0
0
0
7
0
0
0
0
0
0
0
0
44
0
% N
% Pro:
75
0
0
0
0
7
0
0
0
0
0
0
0
0
7
% P
% Gln:
0
7
0
0
0
0
0
0
0
7
0
0
0
0
0
% Q
% Arg:
0
0
0
0
25
0
0
0
0
57
0
0
0
0
7
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
13
0
% S
% Thr:
0
0
0
0
0
0
0
82
0
0
0
0
0
7
0
% T
% Val:
0
0
0
7
0
0
0
13
0
0
0
0
7
0
0
% V
% Trp:
0
7
0
0
0
0
0
0
0
0
0
0
94
0
0
% W
% Tyr:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _