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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CFL1
All Species:
42.12
Human Site:
S120
Identified Species:
77.22
UniProt:
P23528
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P23528
NP_005498.1
166
18502
S120
S
K
M
I
Y
A
S
S
K
D
A
I
K
K
K
Chimpanzee
Pan troglodytes
XP_509898
289
31289
S243
S
K
M
I
Y
A
S
S
K
D
A
I
K
K
K
Rhesus Macaque
Macaca mulatta
XP_001118077
454
48753
S408
S
K
M
I
Y
A
S
S
K
D
A
I
K
K
K
Dog
Lupus familis
XP_851281
242
25771
S138
S
K
M
I
Y
A
S
S
K
D
A
I
K
K
K
Cat
Felis silvestris
Mouse
Mus musculus
P18760
166
18541
S120
S
K
M
I
Y
A
S
S
K
D
A
I
K
K
K
Rat
Rattus norvegicus
P45592
166
18514
S120
S
K
M
I
Y
A
S
S
K
D
A
I
K
K
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512147
253
27590
S207
S
K
M
I
Y
A
S
S
K
D
A
I
K
K
K
Chicken
Gallus gallus
P21566
166
18643
S120
S
K
M
I
Y
A
S
S
K
D
A
I
K
K
K
Frog
Xenopus laevis
Q5XHH8
167
18839
S120
S
K
M
I
Y
A
S
S
K
D
A
I
K
K
K
Zebra Danio
Brachydanio rerio
NP_991263
166
18550
S120
S
K
M
I
Y
A
S
S
K
D
A
I
K
K
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q41764
139
15881
S94
Y
I
L
W
S
P
S
S
A
K
V
K
S
K
M
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q39250
139
16094
I94
F
I
A
W
C
P
D
I
A
K
V
R
S
K
M
Baker's Yeast
Sacchar. cerevisiae
Q03048
143
15882
K98
D
T
A
P
V
R
S
K
M
V
Y
A
S
S
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
46.7
36.3
66.1
N.A.
98.8
99.4
N.A.
54.5
81.9
78.4
80.1
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
52.2
36.3
66.5
N.A.
99.4
99.4
N.A.
60
89.7
88
89.7
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
33.1
N.A.
34.9
36.7
N.A.
Protein Similarity:
N.A.
48.8
N.A.
53
56
N.A.
P-Site Identity:
N.A.
20
N.A.
6.6
13.3
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
6.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
16
0
0
77
0
0
16
0
77
8
0
0
0
% A
% Cys:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
0
0
8
0
0
77
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
16
0
77
0
0
0
8
0
0
0
77
0
0
0
% I
% Lys:
0
77
0
0
0
0
0
8
77
16
0
8
77
93
85
% K
% Leu:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
77
0
0
0
0
0
8
0
0
0
0
0
16
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
8
0
16
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
8
0
0
0
0
0
8
0
0
0
% R
% Ser:
77
0
0
0
8
0
93
85
0
0
0
0
24
8
0
% S
% Thr:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
8
0
0
0
0
8
16
0
0
0
0
% V
% Trp:
0
0
0
16
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
77
0
0
0
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _