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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CYP7A1
All Species:
23.33
Human Site:
T422
Identified Species:
51.33
UniProt:
P22680
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P22680
NP_000771.2
504
57661
T422
E
N
G
K
T
K
T
T
F
Y
C
N
G
L
K
Chimpanzee
Pan troglodytes
XP_519773
504
57628
T422
E
N
G
K
T
K
T
T
F
Y
C
N
G
L
K
Rhesus Macaque
Macaca mulatta
XP_001087135
504
57781
T422
E
N
G
K
T
K
T
T
F
Y
C
N
G
L
K
Dog
Lupus familis
XP_544091
501
57140
T419
E
N
G
K
T
K
T
T
F
Y
S
N
G
I
K
Cat
Felis silvestris
Mouse
Mus musculus
Q64505
503
57240
T422
E
S
G
K
A
K
T
T
F
Y
R
N
G
N
K
Rat
Rattus norvegicus
P18125
503
56864
T422
E
S
G
K
A
K
T
T
F
Y
S
N
G
N
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514400
507
57946
N425
E
N
G
K
T
K
T
N
F
Y
C
N
G
L
K
Chicken
Gallus gallus
NP_001001753
513
59294
D431
E
N
K
E
E
K
T
D
F
Y
R
N
G
R
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_957467
512
58721
T429
D
E
K
G
Q
E
K
T
A
F
Y
R
N
G
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W011
510
58195
P429
P
D
P
L
S
F
R
P
E
R
F
L
E
D
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9C5Y2
489
56732
S414
D
P
K
K
F
D
P
S
R
W
E
G
Y
T
P
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
96.2
84.9
N.A.
81.5
82.3
N.A.
75.1
65.8
N.A.
63.4
N.A.
22.1
N.A.
N.A.
N.A.
Protein Similarity:
100
100
98.6
92.2
N.A.
90.8
90.6
N.A.
88.3
83
N.A.
80.8
N.A.
40.5
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
86.6
N.A.
73.3
73.3
N.A.
93.3
60
N.A.
6.6
N.A.
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
80
80
N.A.
93.3
66.6
N.A.
33.3
N.A.
20
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.4
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
40.2
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
19
0
0
0
10
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
37
0
0
0
0
% C
% Asp:
19
10
0
0
0
10
0
10
0
0
0
0
0
10
0
% D
% Glu:
73
10
0
10
10
10
0
0
10
0
10
0
10
0
0
% E
% Phe:
0
0
0
0
10
10
0
0
73
10
10
0
0
0
0
% F
% Gly:
0
0
64
10
0
0
0
0
0
0
0
10
73
10
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% I
% Lys:
0
0
28
73
0
73
10
0
0
0
0
0
0
0
73
% K
% Leu:
0
0
0
10
0
0
0
0
0
0
0
10
0
37
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
55
0
0
0
0
0
10
0
0
0
73
10
19
0
% N
% Pro:
10
10
10
0
0
0
10
10
0
0
0
0
0
0
10
% P
% Gln:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
10
% Q
% Arg:
0
0
0
0
0
0
10
0
10
10
19
10
0
10
10
% R
% Ser:
0
19
0
0
10
0
0
10
0
0
19
0
0
0
0
% S
% Thr:
0
0
0
0
46
0
73
64
0
0
0
0
0
10
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
73
10
0
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _