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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FDXR All Species: 32.73
Human Site: S317 Identified Species: 55.38
UniProt: P22570 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P22570 NP_004101.2 491 53837 S317 S P Q Q V L P S P D G R R A A
Chimpanzee Pan troglodytes XP_001137746 494 53873 S320 S P Q Q V L P S P D G R R A A
Rhesus Macaque Macaca mulatta XP_001091261 492 53992 S318 S P Q Q V L P S P D G R R A A
Dog Lupus familis XP_533117 492 54038 S318 S P Q Q V L P S P D G R R A A
Cat Felis silvestris
Mouse Mus musculus Q61578 494 54184 T320 S P Q Q V L P T P D G Q R V A
Rat Rattus norvegicus P56522 494 54344 T320 S P Q Q V L P T P D G R R V A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513817 497 53440 S323 S P V E V L A S P D G V R A A
Chicken Gallus gallus XP_001232923 471 51228 T296 S P Q E V L P T A D G M R V R
Frog Xenopus laevis NP_001088306 486 53595 S311 S P F A V L P S E D G K R A A
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V3T9 466 51334 I291 G S K Q F L P I F L R A P K A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_790150 503 55169 L319 E V L S S S P L G E N G R V A
Poplar Tree Populus trichocarpa XP_002301734 496 54084 G310 P D R F L D S G E G S G R V A
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_194962 483 53051 D301 P D Q F L E S D E R K G H V S
Baker's Yeast Sacchar. cerevisiae P48360 493 56219 L315 L D Y L K T P L K I N R D D F
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 91.3 97.7 89.8 N.A. 86.6 86.8 N.A. 76 65.9 66.1 N.A. N.A. 46.6 N.A. N.A. 52.8
Protein Similarity: 100 92.9 98.3 93.9 N.A. 91.3 92.1 N.A. 83.3 78.4 76.3 N.A. N.A. 62.5 N.A. N.A. 67.7
P-Site Identity: 100 100 100 100 N.A. 80 86.6 N.A. 73.3 60 73.3 N.A. N.A. 26.6 N.A. N.A. 20
P-Site Similarity: 100 100 100 100 N.A. 93.3 93.3 N.A. 80 73.3 80 N.A. N.A. 33.3 N.A. N.A. 26.6
Percent
Protein Identity: 47.5 N.A. N.A. 46.4 35.2 N.A.
Protein Similarity: 61 N.A. N.A. 60.9 54.9 N.A.
P-Site Identity: 13.3 N.A. N.A. 6.6 13.3 N.A.
P-Site Similarity: 26.6 N.A. N.A. 20 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 0 0 8 0 8 0 0 8 0 43 79 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 22 0 0 0 8 0 8 0 65 0 0 8 8 0 % D
% Glu: 8 0 0 15 0 8 0 0 22 8 0 0 0 0 0 % E
% Phe: 0 0 8 15 8 0 0 0 8 0 0 0 0 0 8 % F
% Gly: 8 0 0 0 0 0 0 8 8 8 65 22 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % H
% Ile: 0 0 0 0 0 0 0 8 0 8 0 0 0 0 0 % I
% Lys: 0 0 8 0 8 0 0 0 8 0 8 8 0 8 0 % K
% Leu: 8 0 8 8 15 72 0 15 0 8 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 15 0 0 0 0 % N
% Pro: 15 65 0 0 0 0 79 0 50 0 0 0 8 0 0 % P
% Gln: 0 0 58 50 0 0 0 0 0 0 0 8 0 0 0 % Q
% Arg: 0 0 8 0 0 0 0 0 0 8 8 43 79 0 8 % R
% Ser: 65 8 0 8 8 8 15 43 0 0 8 0 0 0 8 % S
% Thr: 0 0 0 0 0 8 0 22 0 0 0 0 0 0 0 % T
% Val: 0 8 8 0 65 0 0 0 0 0 0 8 0 43 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _