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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GART All Species: 23.64
Human Site: S625 Identified Species: 47.27
UniProt: P22102 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P22102 NP_000810.1 1010 107767 S625 G L H S N G F S L V R K I V A
Chimpanzee Pan troglodytes XP_514869 1010 107704 S625 G L H S N G F S L V R K I V A
Rhesus Macaque Macaca mulatta XP_001093303 909 97049 A562 I A K A C G K A G C A L L G G
Dog Lupus familis XP_544864 745 79854 E402 N L L L A L E E A K K G L S A
Cat Felis silvestris
Mouse Mus musculus Q64737 1010 107377 S625 G L H S N G F S L V R K I V E
Rat Rattus norvegicus NP_001011899 1010 107561 S625 G L H S N G F S L V R K I V E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513896 1008 107242 S625 G L H S N G F S L V R K I V E
Chicken Gallus gallus P21872 1003 106526 Y624 S G V H S N G Y S L V R R I V
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_571692 1017 107609 S626 G I H S N G F S L V R T I L E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P00967 1353 144430 I634 H C A G F N E I L T Q L A A S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_785897 1012 107051 Y629 S G I H S N G Y S L V R R L V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P07244 802 86050 V459 Y A D S G V S V D N G N N L V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 86.8 66.9 N.A. 85.6 86.5 N.A. 79.8 74.3 N.A. 66.8 N.A. 37.7 N.A. N.A. 58.9
Protein Similarity: 100 99.6 88.5 70.5 N.A. 93.7 93.8 N.A. 89.1 86.7 N.A. 81.3 N.A. 51.9 N.A. N.A. 73.5
P-Site Identity: 100 100 6.6 13.3 N.A. 93.3 93.3 N.A. 93.3 0 N.A. 73.3 N.A. 6.6 N.A. N.A. 0
P-Site Similarity: 100 100 26.6 26.6 N.A. 93.3 93.3 N.A. 93.3 26.6 N.A. 86.6 N.A. 20 N.A. N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 37.2 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 52.7 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 17 9 9 9 0 0 9 9 0 9 0 9 9 25 % A
% Cys: 0 9 0 0 9 0 0 0 0 9 0 0 0 0 0 % C
% Asp: 0 0 9 0 0 0 0 0 9 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 17 9 0 0 0 0 0 0 34 % E
% Phe: 0 0 0 0 9 0 50 0 0 0 0 0 0 0 0 % F
% Gly: 50 17 0 9 9 59 17 0 9 0 9 9 0 9 9 % G
% His: 9 0 50 17 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 9 9 9 0 0 0 0 9 0 0 0 0 50 9 0 % I
% Lys: 0 0 9 0 0 0 9 0 0 9 9 42 0 0 0 % K
% Leu: 0 50 9 9 0 9 0 0 59 17 0 17 17 25 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 9 0 0 0 50 25 0 0 0 9 0 9 9 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 50 17 17 0 0 % R
% Ser: 17 0 0 59 17 0 9 50 17 0 0 0 0 9 9 % S
% Thr: 0 0 0 0 0 0 0 0 0 9 0 9 0 0 0 % T
% Val: 0 0 9 0 0 9 0 9 0 50 17 0 0 42 25 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 9 0 0 0 0 0 0 17 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _