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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: OSBP All Species: 36.36
Human Site: S715 Identified Species: 66.67
UniProt: P22059 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P22059 NP_002547.1 807 89421 S715 S G T A P T D S R L R P D Q R
Chimpanzee Pan troglodytes XP_508451 807 89429 S715 S G T A P T D S R L R P D Q R
Rhesus Macaque Macaca mulatta XP_001090190 805 89207 S713 S G T A P T D S R L R P D Q R
Dog Lupus familis XP_540566 1109 121200 S1017 S G T A P T D S R L R P D Q R
Cat Felis silvestris
Mouse Mus musculus Q3B7Z2 751 84671 S659 G G T A P T D S R L R P D Q R
Rat Rattus norvegicus Q8K4M9 950 107747 P868 K E M E T V I P K T D C R L R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505999 738 84284 E662 M E N G R W D E A N A E K Q R
Chicken Gallus gallus XP_415293 788 88247 S696 E R V A P T D S R L R P D Q R
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001139057 760 85799 S666 E G V A P T D S R K R P D Q R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477271 784 89306 S692 E G V A P T D S R L R P D Q R
Honey Bee Apis mellifera XP_392480 836 95642 S744 E G V A P T D S R F R P D Q R
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_790853 566 64483 H491 I F P Q G T A H I T F K K S G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P35845 1188 135079 S1106 P Y L A P T D S R L R P D Q R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 99.5 71.2 N.A. 90.5 29.4 N.A. 83.8 68.9 N.A. 68.4 N.A. 34.3 49.6 N.A. 42.8
Protein Similarity: 100 100 99.7 72.3 N.A. 91.9 42.8 N.A. 86.4 78.9 N.A. 78 N.A. 50.9 64 N.A. 52.9
P-Site Identity: 100 100 100 100 N.A. 93.3 6.6 N.A. 20 80 N.A. 80 N.A. 86.6 80 N.A. 6.6
P-Site Similarity: 100 100 100 100 N.A. 93.3 13.3 N.A. 20 80 N.A. 80 N.A. 86.6 80 N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 26.6 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 40.3 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 80 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 80 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 77 0 0 8 0 8 0 8 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % C
% Asp: 0 0 0 0 0 0 85 0 0 0 8 0 77 0 0 % D
% Glu: 31 16 0 8 0 0 0 8 0 0 0 8 0 0 0 % E
% Phe: 0 8 0 0 0 0 0 0 0 8 8 0 0 0 0 % F
% Gly: 8 62 0 8 8 0 0 0 0 0 0 0 0 0 8 % G
% His: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % H
% Ile: 8 0 0 0 0 0 8 0 8 0 0 0 0 0 0 % I
% Lys: 8 0 0 0 0 0 0 0 8 8 0 8 16 0 0 % K
% Leu: 0 0 8 0 0 0 0 0 0 62 0 0 0 8 0 % L
% Met: 8 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 8 0 0 0 0 0 0 8 0 0 0 0 0 % N
% Pro: 8 0 8 0 77 0 0 8 0 0 0 77 0 0 0 % P
% Gln: 0 0 0 8 0 0 0 0 0 0 0 0 0 85 0 % Q
% Arg: 0 8 0 0 8 0 0 0 77 0 77 0 8 0 93 % R
% Ser: 31 0 0 0 0 0 0 77 0 0 0 0 0 8 0 % S
% Thr: 0 0 39 0 8 85 0 0 0 16 0 0 0 0 0 % T
% Val: 0 0 31 0 0 8 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _