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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IMPDH1
All Species:
34.85
Human Site:
Y430
Identified Species:
63.89
UniProt:
P20839
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P20839
NP_001096075.1
514
55406
Y430
S
S
S
S
Q
K
R
Y
F
S
E
G
D
K
V
Chimpanzee
Pan troglodytes
XP_516452
608
66107
Y524
H
L
S
S
Q
N
R
Y
F
S
E
A
D
K
I
Rhesus Macaque
Macaca mulatta
XP_001089341
530
57059
Y446
S
S
S
S
Q
K
R
Y
F
S
E
G
D
K
V
Dog
Lupus familis
XP_850999
611
65030
Y527
S
S
S
S
Q
K
R
Y
F
S
E
G
D
K
V
Cat
Felis silvestris
Mouse
Mus musculus
P50096
514
55276
Y430
S
S
S
S
Q
K
R
Y
F
S
E
G
D
K
V
Rat
Rattus norvegicus
NP_001102089
548
58591
Y464
S
S
S
S
Q
K
R
Y
F
S
E
G
D
K
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509219
535
57111
L451
C
P
L
A
H
R
A
L
W
G
E
G
D
K
V
Chicken
Gallus gallus
NP_001025772
514
55540
Y430
N
L
G
S
Q
N
R
Y
F
S
E
T
D
K
I
Frog
Xenopus laevis
NP_001080792
514
55674
Y430
S
T
S
S
Q
K
R
Y
F
S
E
G
D
K
V
Zebra Danio
Brachydanio rerio
NP_001014391
514
55622
Y430
N
T
S
S
Q
K
R
Y
F
S
E
G
D
K
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q07152
537
57811
M449
G
D
A
K
G
A
A
M
S
R
Y
Y
H
N
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SA34
502
54033
G420
G
S
D
Q
R
Y
L
G
D
T
A
K
L
K
I
Baker's Yeast
Sacchar. cerevisiae
P50094
524
56375
S435
T
G
N
K
G
N
A
S
T
S
R
Y
F
S
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
71.2
92.4
80.6
N.A.
97.2
87.9
N.A.
85.2
83.6
92
90.6
N.A.
66.1
N.A.
N.A.
N.A.
Protein Similarity:
100
77.6
92.8
82
N.A.
98.8
88.8
N.A.
87
92
96.5
96.3
N.A.
80.4
N.A.
N.A.
N.A.
P-Site Identity:
100
66.6
100
100
N.A.
100
100
N.A.
33.3
60
93.3
86.6
N.A.
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
73.3
100
100
N.A.
100
100
N.A.
53.3
73.3
100
100
N.A.
6.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
46.6
61.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
64.7
77.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
8
0
8
24
0
0
0
8
8
0
0
0
% A
% Cys:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
8
0
0
0
0
0
8
0
0
0
77
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
77
0
0
0
16
% E
% Phe:
0
0
0
0
0
0
0
0
70
0
0
0
8
0
0
% F
% Gly:
16
8
8
0
16
0
0
8
0
8
0
62
0
0
0
% G
% His:
8
0
0
0
8
0
0
0
0
0
0
0
8
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
24
% I
% Lys:
0
0
0
16
0
54
0
0
0
0
0
8
0
85
0
% K
% Leu:
0
16
8
0
0
0
8
8
0
0
0
0
8
0
0
% L
% Met:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% M
% Asn:
16
0
8
0
0
24
0
0
0
0
0
0
0
8
0
% N
% Pro:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
8
70
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
8
8
70
0
0
8
8
0
0
0
0
% R
% Ser:
47
47
62
70
0
0
0
8
8
77
0
0
0
8
0
% S
% Thr:
8
16
0
0
0
0
0
0
8
8
0
8
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
62
% V
% Trp:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
70
0
0
8
16
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _