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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IMPDH1
All Species:
34.55
Human Site:
Y282
Identified Species:
63.33
UniProt:
P20839
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P20839
NP_001096075.1
514
55406
Y282
S
S
Q
G
N
S
V
Y
Q
I
A
M
V
H
Y
Chimpanzee
Pan troglodytes
XP_516452
608
66107
F352
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
Rhesus Macaque
Macaca mulatta
XP_001089341
530
57059
Y298
S
S
Q
G
N
S
V
Y
Q
I
A
M
V
H
Y
Dog
Lupus familis
XP_850999
611
65030
Y379
S
S
Q
G
N
S
V
Y
Q
I
A
M
V
H
Y
Cat
Felis silvestris
Mouse
Mus musculus
P50096
514
55276
Y282
S
S
Q
G
N
S
V
Y
Q
I
A
M
V
H
Y
Rat
Rattus norvegicus
NP_001102089
548
58591
Y316
S
S
Q
G
N
S
V
Y
Q
I
A
M
V
H
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509219
535
57111
V312
Q
A
G
T
D
V
I
V
L
D
S
S
Q
G
N
Chicken
Gallus gallus
NP_001025772
514
55540
F282
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
Frog
Xenopus laevis
NP_001080792
514
55674
Y282
S
S
Q
G
N
S
V
Y
Q
I
N
M
I
H
Y
Zebra Danio
Brachydanio rerio
NP_001014391
514
55622
Y282
S
S
Q
G
N
S
V
Y
Q
I
N
M
I
H
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q07152
537
57811
Y301
S
S
Q
G
N
S
V
Y
Q
V
E
M
I
K
Y
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SA34
502
54033
Y272
S
S
Q
G
N
S
I
Y
Q
L
E
M
I
K
Y
Baker's Yeast
Sacchar. cerevisiae
P50094
524
56375
F287
S
S
Q
G
N
S
V
F
Q
L
N
M
I
K
W
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
71.2
92.4
80.6
N.A.
97.2
87.9
N.A.
85.2
83.6
92
90.6
N.A.
66.1
N.A.
N.A.
N.A.
Protein Similarity:
100
77.6
92.8
82
N.A.
98.8
88.8
N.A.
87
92
96.5
96.3
N.A.
80.4
N.A.
N.A.
N.A.
P-Site Identity:
100
66.6
100
100
N.A.
100
100
N.A.
0
66.6
86.6
86.6
N.A.
73.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
86.6
100
100
N.A.
100
100
N.A.
26.6
86.6
93.3
93.3
N.A.
86.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
46.6
61.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
64.7
77.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
66.6
60
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
86.6
86.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
0
0
0
0
0
39
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
8
0
0
0
0
8
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
16
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
24
0
0
0
0
0
0
0
% F
% Gly:
0
0
8
93
0
0
0
0
0
0
0
0
0
8
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
54
0
% H
% Ile:
0
0
0
0
0
0
31
0
0
70
0
0
54
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
39
0
% K
% Leu:
0
0
0
0
0
0
0
0
8
16
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
93
0
0
0
% M
% Asn:
0
0
0
0
93
0
0
0
0
0
39
0
0
0
8
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
8
0
93
0
0
0
0
0
93
0
0
0
8
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
93
93
0
0
0
93
0
0
0
0
8
8
0
0
0
% S
% Thr:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
8
70
8
0
8
0
0
39
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
0
0
0
0
0
0
0
70
0
0
0
0
0
0
85
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _