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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IMPDH1
All Species:
39.7
Human Site:
Y233
Identified Species:
72.78
UniProt:
P20839
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P20839
NP_001096075.1
514
55406
Y233
D
L
K
K
N
R
D
Y
P
L
A
S
K
D
S
Chimpanzee
Pan troglodytes
XP_516452
608
66107
Y303
D
L
K
K
N
R
D
Y
P
L
A
S
K
D
A
Rhesus Macaque
Macaca mulatta
XP_001089341
530
57059
Y249
D
L
K
K
N
R
D
Y
P
L
A
S
K
D
S
Dog
Lupus familis
XP_850999
611
65030
Y330
D
L
K
K
N
R
D
Y
P
L
A
S
K
D
S
Cat
Felis silvestris
Mouse
Mus musculus
P50096
514
55276
Y233
D
L
K
K
N
R
D
Y
P
L
A
S
K
D
S
Rat
Rattus norvegicus
NP_001102089
548
58591
Y267
D
L
K
K
N
R
D
Y
P
L
A
S
K
D
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509219
535
57111
A263
D
E
L
V
A
I
I
A
R
T
D
L
K
K
N
Chicken
Gallus gallus
NP_001025772
514
55540
Y233
D
L
K
K
N
R
D
Y
P
L
A
S
K
D
S
Frog
Xenopus laevis
NP_001080792
514
55674
Y233
D
L
K
K
N
R
D
Y
P
L
A
S
K
D
C
Zebra Danio
Brachydanio rerio
NP_001014391
514
55622
Y233
D
L
K
K
N
R
D
Y
P
L
A
S
K
D
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q07152
537
57811
Y252
D
L
K
K
A
R
S
Y
P
N
A
S
K
D
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SA34
502
54033
L223
R
V
K
G
Y
P
K
L
G
S
G
T
V
G
A
Baker's Yeast
Sacchar. cerevisiae
P50094
524
56375
P238
L
M
K
N
Q
N
Y
P
L
A
S
K
S
A
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
71.2
92.4
80.6
N.A.
97.2
87.9
N.A.
85.2
83.6
92
90.6
N.A.
66.1
N.A.
N.A.
N.A.
Protein Similarity:
100
77.6
92.8
82
N.A.
98.8
88.8
N.A.
87
92
96.5
96.3
N.A.
80.4
N.A.
N.A.
N.A.
P-Site Identity:
100
93.3
100
100
N.A.
100
100
N.A.
13.3
100
93.3
100
N.A.
80
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
20
100
93.3
100
N.A.
80
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
46.6
61.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
64.7
77.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
16
0
0
8
0
8
77
0
0
8
16
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% C
% Asp:
85
0
0
0
0
0
70
0
0
0
8
0
0
77
0
% D
% Glu:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
8
0
0
0
0
8
0
8
0
0
8
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
8
8
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
93
77
0
0
8
0
0
0
0
8
85
8
0
% K
% Leu:
8
77
8
0
0
0
0
8
8
70
0
8
0
0
0
% L
% Met:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
70
8
0
0
0
8
0
0
0
0
8
% N
% Pro:
0
0
0
0
0
8
0
8
77
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
8
0
0
0
0
77
0
0
8
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
8
0
0
8
8
77
8
0
62
% S
% Thr:
0
0
0
0
0
0
0
0
0
8
0
8
0
0
8
% T
% Val:
0
8
0
8
0
0
0
0
0
0
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
8
77
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _