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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IMPDH1
All Species:
39.7
Human Site:
S452
Identified Species:
72.78
UniProt:
P20839
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P20839
NP_001096075.1
514
55406
S452
G
S
I
Q
D
K
G
S
I
Q
K
F
V
P
Y
Chimpanzee
Pan troglodytes
XP_516452
608
66107
S546
G
A
V
Q
D
K
G
S
I
H
K
F
V
P
Y
Rhesus Macaque
Macaca mulatta
XP_001089341
530
57059
S468
G
S
I
Q
D
K
G
S
I
Q
K
F
V
P
Y
Dog
Lupus familis
XP_850999
611
65030
S549
G
S
I
Q
D
K
G
S
I
Q
K
F
V
P
Y
Cat
Felis silvestris
Mouse
Mus musculus
P50096
514
55276
S452
G
S
I
Q
D
K
G
S
I
Q
K
F
V
P
Y
Rat
Rattus norvegicus
NP_001102089
548
58591
S486
G
S
I
Q
D
K
G
S
I
Q
K
F
V
P
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509219
535
57111
S473
G
S
I
Q
D
K
G
S
I
Q
K
F
V
P
Y
Chicken
Gallus gallus
NP_001025772
514
55540
S452
G
A
V
Q
D
K
G
S
I
H
K
F
I
P
Y
Frog
Xenopus laevis
NP_001080792
514
55674
S452
G
S
I
Q
D
K
G
S
I
H
K
F
V
P
Y
Zebra Danio
Brachydanio rerio
NP_001014391
514
55622
S452
G
S
V
Q
D
K
G
S
I
H
K
F
V
P
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q07152
537
57811
V471
Q
G
V
S
G
S
I
V
D
K
G
S
V
L
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SA34
502
54033
L442
V
A
D
K
G
S
V
L
K
F
I
P
Y
T
M
Baker's Yeast
Sacchar. cerevisiae
P50094
524
56375
V457
Q
G
V
S
G
A
V
V
D
K
G
S
I
K
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
71.2
92.4
80.6
N.A.
97.2
87.9
N.A.
85.2
83.6
92
90.6
N.A.
66.1
N.A.
N.A.
N.A.
Protein Similarity:
100
77.6
92.8
82
N.A.
98.8
88.8
N.A.
87
92
96.5
96.3
N.A.
80.4
N.A.
N.A.
N.A.
P-Site Identity:
100
80
100
100
N.A.
100
100
N.A.
100
73.3
93.3
86.6
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
93.3
100
100
N.A.
100
100
N.A.
100
93.3
93.3
93.3
N.A.
20
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
46.6
61.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
64.7
77.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
24
0
0
0
8
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
77
0
0
0
16
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
8
0
77
0
0
0
% F
% Gly:
77
16
0
0
24
0
77
0
0
0
16
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
31
0
0
0
0
0
% H
% Ile:
0
0
54
0
0
0
8
0
77
0
8
0
16
0
0
% I
% Lys:
0
0
0
8
0
77
0
0
8
16
77
0
0
8
8
% K
% Leu:
0
0
0
0
0
0
0
8
0
0
0
0
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
8
0
77
0
% P
% Gln:
16
0
0
77
0
0
0
0
0
47
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% R
% Ser:
0
62
0
16
0
16
0
77
0
0
0
16
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% T
% Val:
8
0
39
0
0
0
16
16
0
0
0
0
77
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
77
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _