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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: COX5A All Species: 10.3
Human Site: S25 Identified Species: 16.19
UniProt: P20674 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P20674 NP_004246.2 150 16762 S25 D P R G L L H S A R T P G P A
Chimpanzee Pan troglodytes B0VYX1 150 16630 S25 G P R G L L H S A R T P G P A
Rhesus Macaque Macaca mulatta Q53CF8 150 16651 S25 G P R G L L H S A R T P G P A
Dog Lupus familis XP_853952 151 16625 P26 S P Q G L R Y P A P A P S P A
Cat Felis silvestris
Mouse Mus musculus P12787 146 16083 P21 A A R G L L H P A S A P S P A
Rat Rattus norvegicus P11240 146 16111 P21 A A R G L L H P V S A P S P A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511903 376 41939 Y251 D K L E I F V Y V S V L M S I
Chicken Gallus gallus
Frog Xenopus laevis NP_001085392 148 16448 L23 R S L P R C R L Q S V S A G S
Zebra Danio Brachydanio rerio XP_700576 172 19236 L47 V L R G F L G L S R T R A A Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q94514 149 16604 T20 L R S S L V G T S S R V A A V
Honey Bee Apis mellifera XP_392368 152 17602 V23 S L I P Y N T V I R Q N I R A
Nematode Worm Caenorhab. elegans P55954 174 20092 V19 A I A G R Q A V R T I A T T T
Sea Urchin Strong. purpuratus XP_784558 149 16879 P19 A V R S T V I P R N L Q Q P L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P00427 148 17323 H25 R A R P G A Y H A T R L T K N
Red Bread Mold Neurospora crassa Q01359 148 16785 Q24 F R A V A R P Q P I A A R V S
Conservation
Percent
Protein Identity: 100 98 96 86.7 N.A. 86 85.3 N.A. 35.6 N.A. 78 60.4 N.A. 48.6 48 36.7 59.3
Protein Similarity: 100 98 96.6 90 N.A. 88.6 88 N.A. 36.7 N.A. 85.3 70.9 N.A. 64 67.7 54 70.6
P-Site Identity: 100 93.3 93.3 46.6 N.A. 60 53.3 N.A. 6.6 N.A. 0 33.3 N.A. 6.6 13.3 6.6 13.3
P-Site Similarity: 100 93.3 93.3 60 N.A. 60 53.3 N.A. 13.3 N.A. 6.6 40 N.A. 26.6 13.3 6.6 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 35.3 32
Protein Similarity: N.A. N.A. N.A. N.A. 50.6 48.6
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 0
P-Site Similarity: N.A. N.A. N.A. N.A. 20 6.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 27 20 14 0 7 7 7 0 40 0 27 14 20 14 47 % A
% Cys: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % C
% Asp: 14 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 7 0 0 0 7 7 0 0 0 0 0 0 0 0 0 % F
% Gly: 14 0 0 54 7 0 14 0 0 0 0 0 20 7 0 % G
% His: 0 0 0 0 0 0 34 7 0 0 0 0 0 0 0 % H
% Ile: 0 7 7 0 7 0 7 0 7 7 7 0 7 0 7 % I
% Lys: 0 7 0 0 0 0 0 0 0 0 0 0 0 7 0 % K
% Leu: 7 14 14 0 47 40 0 14 0 0 7 14 0 0 7 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % M
% Asn: 0 0 0 0 0 7 0 0 0 7 0 7 0 0 7 % N
% Pro: 0 27 0 20 0 0 7 27 7 7 0 40 0 47 0 % P
% Gln: 0 0 7 0 0 7 0 7 7 0 7 7 7 0 7 % Q
% Arg: 14 14 54 0 14 14 7 0 14 34 14 7 7 7 0 % R
% Ser: 14 7 7 14 0 0 0 20 14 34 0 7 20 7 14 % S
% Thr: 0 0 0 0 7 0 7 7 0 14 27 0 14 7 7 % T
% Val: 7 7 0 7 0 14 7 14 14 0 14 7 0 7 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 7 0 14 7 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _