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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
M6PR
All Species:
18.18
Human Site:
Y122
Identified Species:
36.36
UniProt:
P20645
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P20645
NP_002346.1
277
30993
Y122
S
N
W
I
M
L
I
Y
K
G
G
D
E
Y
D
Chimpanzee
Pan troglodytes
XP_001137994
244
27171
G114
N
E
T
H
I
F
N
G
S
N
W
I
M
L
I
Rhesus Macaque
Macaca mulatta
XP_001113975
278
31085
Y123
S
N
W
I
M
L
I
Y
K
G
G
D
E
Y
D
Dog
Lupus familis
XP_534894
396
43228
Y241
S
N
W
I
M
L
I
Y
K
G
G
D
E
Y
D
Cat
Felis silvestris
Mouse
Mus musculus
P24668
278
31154
Y123
S
N
W
I
M
L
I
Y
K
G
G
D
E
Y
D
Rat
Rattus norvegicus
Q6AY20
278
31077
Y123
S
N
W
I
M
L
I
Y
K
G
G
D
E
Y
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514710
258
28364
N127
R
V
C
R
E
A
G
N
G
T
S
G
A
G
L
Chicken
Gallus gallus
XP_416477
298
33190
R129
A
Y
H
F
R
V
C
R
E
V
N
S
S
L
H
Frog
Xenopus laevis
NP_001080870
273
29899
E131
Y
D
S
H
C
N
N
E
A
R
K
A
M
V
M
Zebra Danio
Brachydanio rerio
NP_998370
265
29164
R125
S
H
C
S
S
E
E
R
K
A
M
I
M
I
S
Tiger Blowfish
Takifugu rubipres
NP_001033033
272
30118
Q133
S
C
S
K
D
A
S
Q
A
Q
I
M
I
F
C
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784873
183
20114
N53
E
V
T
D
T
A
K
N
Y
T
Y
K
V
G
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.7
98.9
66.4
N.A.
91.7
91
N.A.
54.1
52
59.2
48.7
42.9
N.A.
N.A.
N.A.
30.3
Protein Similarity:
100
87.7
99.2
68.6
N.A.
95.6
95.6
N.A.
63.9
63.7
72.9
66.7
59.9
N.A.
N.A.
N.A.
42.6
P-Site Identity:
100
0
100
100
N.A.
100
100
N.A.
0
0
0
13.3
6.6
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
13.3
100
100
N.A.
100
100
N.A.
0
20
6.6
20
13.3
N.A.
N.A.
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
0
0
25
0
0
17
9
0
9
9
0
0
% A
% Cys:
0
9
17
0
9
0
9
0
0
0
0
0
0
0
9
% C
% Asp:
0
9
0
9
9
0
0
0
0
0
0
42
0
0
42
% D
% Glu:
9
9
0
0
9
9
9
9
9
0
0
0
42
0
0
% E
% Phe:
0
0
0
9
0
9
0
0
0
0
0
0
0
9
9
% F
% Gly:
0
0
0
0
0
0
9
9
9
42
42
9
0
17
0
% G
% His:
0
9
9
17
0
0
0
0
0
0
0
0
0
0
9
% H
% Ile:
0
0
0
42
9
0
42
0
0
0
9
17
9
9
9
% I
% Lys:
0
0
0
9
0
0
9
0
50
0
9
9
0
0
0
% K
% Leu:
0
0
0
0
0
42
0
0
0
0
0
0
0
17
9
% L
% Met:
0
0
0
0
42
0
0
0
0
0
9
9
25
0
9
% M
% Asn:
9
42
0
0
0
9
17
17
0
9
9
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
9
0
9
0
0
0
0
0
% Q
% Arg:
9
0
0
9
9
0
0
17
0
9
0
0
0
0
0
% R
% Ser:
59
0
17
9
9
0
9
0
9
0
9
9
9
0
9
% S
% Thr:
0
0
17
0
9
0
0
0
0
17
0
0
0
0
0
% T
% Val:
0
17
0
0
0
9
0
0
0
9
0
0
9
9
0
% V
% Trp:
0
0
42
0
0
0
0
0
0
0
9
0
0
0
0
% W
% Tyr:
9
9
0
0
0
0
0
42
9
0
9
0
0
42
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _