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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: M6PR All Species: 18.18
Human Site: S267 Identified Species: 36.36
UniProt: P20645 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P20645 NP_002346.1 277 30993 S267 D D Q L G E E S E E R D D H L
Chimpanzee Pan troglodytes XP_001137994 244 27171 A237 Q D L G N L V A V S N R A A G
Rhesus Macaque Macaca mulatta XP_001113975 278 31085 S268 D D Q L G E E S E E R D D H L
Dog Lupus familis XP_534894 396 43228 S386 D D Q L G E E S E E R D D H L
Cat Felis silvestris
Mouse Mus musculus P24668 278 31154 S268 D D Q L G E E S E E R D D H L
Rat Rattus norvegicus Q6AY20 278 31077 S268 D D Q L G E E S E E R D D H L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514710 258 28364 A250 C R Q G G P R A G P Q T G L A
Chicken Gallus gallus XP_416477 298 33190 W280 Q F P H F A F W Q D L G N L V
Frog Xenopus laevis NP_001080870 273 29899 P263 D D Q L G E E P E E R D D H L
Zebra Danio Brachydanio rerio NP_998370 265 29164 P255 T E P L G E E P E E R D D H L
Tiger Blowfish Takifugu rubipres NP_001033033 272 30118 P262 S E P S E D D P E E R D D H L
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784873 183 20114 R176 G L D E E E E R D E N I L P M
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 87.7 98.9 66.4 N.A. 91.7 91 N.A. 54.1 52 59.2 48.7 42.9 N.A. N.A. N.A. 30.3
Protein Similarity: 100 87.7 99.2 68.6 N.A. 95.6 95.6 N.A. 63.9 63.7 72.9 66.7 59.9 N.A. N.A. N.A. 42.6
P-Site Identity: 100 6.6 100 100 N.A. 100 100 N.A. 13.3 0 93.3 73.3 46.6 N.A. N.A. N.A. 20
P-Site Similarity: 100 13.3 100 100 N.A. 100 100 N.A. 26.6 26.6 93.3 80 66.6 N.A. N.A. N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 9 0 17 0 0 0 0 9 9 9 % A
% Cys: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 50 59 9 0 0 9 9 0 9 9 0 67 67 0 0 % D
% Glu: 0 17 0 9 17 67 67 0 67 75 0 0 0 0 0 % E
% Phe: 0 9 0 0 9 0 9 0 0 0 0 0 0 0 0 % F
% Gly: 9 0 0 17 67 0 0 0 9 0 0 9 9 0 9 % G
% His: 0 0 0 9 0 0 0 0 0 0 0 0 0 67 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 9 9 59 0 9 0 0 0 0 9 0 9 17 67 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % M
% Asn: 0 0 0 0 9 0 0 0 0 0 17 0 9 0 0 % N
% Pro: 0 0 25 0 0 9 0 25 0 9 0 0 0 9 0 % P
% Gln: 17 0 59 0 0 0 0 0 9 0 9 0 0 0 0 % Q
% Arg: 0 9 0 0 0 0 9 9 0 0 67 9 0 0 0 % R
% Ser: 9 0 0 9 0 0 0 42 0 9 0 0 0 0 0 % S
% Thr: 9 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % T
% Val: 0 0 0 0 0 0 9 0 9 0 0 0 0 0 9 % V
% Trp: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _